سامانه مدیریت نشریات علمی دانشگاه شاهد

جهان مهین, محمد, عسکری, رویا, حقیقی, امیر حسین, حجار, تکتم. (1402). تأثیر 10 هفته تمرینات استقامتی در آب بر سالخوردگی سیستم ایمنی رت‌های سالمند. , 31(3), 22-33. doi: 10.22070/daneshmed.2023.17745.1351
محمد جهان مهین; رویا عسکری; امیر حسین حقیقی; تکتم حجار. "تأثیر 10 هفته تمرینات استقامتی در آب بر سالخوردگی سیستم ایمنی رت‌های سالمند". , 31, 3, 1402, 22-33. doi: 10.22070/daneshmed.2023.17745.1351
جهان مهین, محمد, عسکری, رویا, حقیقی, امیر حسین, حجار, تکتم. (1402). 'تأثیر 10 هفته تمرینات استقامتی در آب بر سالخوردگی سیستم ایمنی رت‌های سالمند', , 31(3), pp. 22-33. doi: 10.22070/daneshmed.2023.17745.1351
جهان مهین, محمد, عسکری, رویا, حقیقی, امیر حسین, حجار, تکتم. تأثیر 10 هفته تمرینات استقامتی در آب بر سالخوردگی سیستم ایمنی رت‌های سالمند. , 1402; 31(3): 22-33. doi: 10.22070/daneshmed.2023.17745.1351

تأثیر 10 هفته تمرینات استقامتی در آب بر سالخوردگی سیستم ایمنی رت‌های سالمند

دانشور پزشکی
دوره 31، شماره 3 - شماره پیاپی 166، مرداد و شهریور 1402، صفحه 22-33    اصل مقاله (866.1 K)
نوع مقاله: مقاله پژوهشی
شناسه دیجیتال (DOI): 10.22070/daneshmed.2023.17745.1351
نویسندگان
محمد جهان مهین1؛ رویا عسکری* 1؛ امیر حسین حقیقی1؛ تکتم حجار2
1گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه حکیم سبزواری؛ سبزوار، ایران
2گروه زیست‌شناسی، دانشکده علوم پایه، دانشگاه حکیم سبزواری؛ سبزوار، ایران
چکیده
مقدمه و هدف: مجموعه‌ای از لنفوسیت‌های بکر محدودشده همراه با تجمع سلول‌های T سالخورده و انحلال تیموس از عوامل اصلی ایجادکننده سالخوردگی سیستم ایمنی هستند که با تمرین ورزشی می‌توان این عوامل را تعدیل کرد؛ بنابراین هدف از پژوهش حاضر بررسی 10 هفته تمرین استقامتی در آب بر سالخوردگی سیستم ایمنی در رت‌های سالمند است.
مواد و روش ها: 16 رت 24 ماهه به‌صورت تصادفی به دو گروه تمرین استقامتی (8n=) و کنترل (8n=) تقسیم شدند. تمرینات استقامتی 4 جلسه در هفته در ظرفی به ابعاد 50*50*100 با آب 1±30 درجه سانتی‌گراد اجرا شد. داده‌ها توسط آزمون تی مستقل با نرم‌افزار SPSS ورژن 22 در سطح (05/0P<) آنالیز شدند.
نتایج: تفاوت معناداری بین دو گروه تمرین و کنترل در سلول‌های +TCD4 و TCD8+، لنفوسیت‌های بکرCD8+ ، CD8+ سالخورده، CD8+ بکر سالخورده وجود داشت (01/0P=)، درحالی‌که در دو شاخص وزن تیموس (43/0P=) و نسبت CD4+/CD8+ تفاوت معناداری مشاهده نشد (29/0P=).
نتیجه‌گیری: درنهایت، نتایج این مطالعه نشان می‌دهد که تمرینات استقامتی در آب یک فعالیت ایمن برای سالمندان به‌منظور بهبود سیستم ایمنی و کاهش سالخوردگی سلول‌های T است.
کلیدواژه‌ها
سالخوردگی سیستم ایمنی؛ لنفوسیت T؛ تمرین استقامتی؛ TCD4+؛ TCD8+
مراجع
  1. Witkowski JM, Fulop T, Bryl E. Immunosenescence and COVID-19. Mechanisms of Ageing and Development. 2022; 204:111672.
  2. Saule P, Trauet J, Dutriez V, Lekeux V, Dessaint JP, Labalette M. Accumulation of memory T cells from childhood to old age: central and effector memory cells in CD4+ versus effector memory and terminally differentiated memory cells in CD8+ compartment. Mechanisms of ageing and development. 2006; 127(3):274-81.
  3. Palmer DB. The effect of age on thymic function. Frontiers in immunology. 2013; 4:316.
  4. Cao Dinh H, Njemini R, Onyema OO, Beyer I, Liberman K, De Dobbeleer L, Renmans W, Vander Meeren S, Jochmans K, Delaere A, Knoop V. Strength endurance training but not intensive strength training reduces senescence-prone T cells in peripheral blood in community-dwelling elderly women. The Journals of Gerontology: Series A. 2019; 74(12):1870-8.
  5. Van Deursen JM. The role of senescent cells in ageing. Nature. 2014; 509(7501):439-46.
  6. Yuan J, Liu Y, Wang J, Zhao Y, Li K, Jing Y, Zhang X, Liu Q, Geng X, Li G, Wang F. Long-term persistent organic pollutants exposure induced telomere dysfunction and senescence-associated secretary phenotype. The Journals of Gerontology: Series A. 2018; 73(8):1027-35.
  7. Davalos AR, Coppe JP, Campisi J, Desprez PY. Senescent cells as a source of inflammatory factors for tumor progression. Cancer and Metastasis Reviews. 2010 Jun; 29(2):273-83.
  8. Estruel-Amades S, Ruiz-Iglesias P, Périz M, Franch À, Pérez-Cano FJ, Camps-Bossacoma M, Castell M. Changes in lymphocyte composition and functionality after intensive training and exhausting exercise in rats. Frontiers in Physiology. 2019; 10:1491.
  9. Akunuru S, Geiger H. Aging, clonality, and rejuvenation of hematopoietic stem cells. Trends in molecular medicine. 2016; 22(8):701-12.
  10. Spica VR, Macini P, Galeone D, Liguori G, Signorelli C, Marensi L, Vagali P, Guberti E, Goletti M, Mammina C, Tabacchi G. Adapted physical activity for the promotion of health and the prevention of multifactorial chronic diseases: the Erice Charter.
  11. Valdiglesias V, Sánchez-Flores M, Maseda A, Lorenzo-López L, Marcos-Pérez D, López-Cortón A, Strasser B, Fuchs D, Laffon B, Millán-Calenti JC, Pásaro E. Immune biomarkers in older adults: Role of physical activity. Journal of Toxicology and Environmental Health, Part A. 2017; 80(13-15):605-20.
  12. De Araújo AL, Silva LC, Fernandes JR, Benard G. Preventing or reversing immunosenescence: can exercise be an immunotherapy? Immunotherapy. 2013; 5(8):879-93.
  13. Merellano-Navarro E, Olate-Briones A, Norambuena-Mardones L, Rojas-Ramos V, de la Plata-Luna AM, Faúndez-Acuña JY, Moraga JC, Escobedo N, Herrada AA. Reduced Naïve T Cell Numbers Correlate with Increased Low-Grade Systemic Inflammation during Ageing and can be modulated by Physical Activity. International Journal of Morphology. 2021; 39(3).
  14. Alves AS, Bueno V. Imunosenescência: participação de linfócitos T e células mieloides supressoras nas alterações da resposta imune relacionadas ao envelhecimento. Einstein (São Paulo). 2019; 17.
  15. Drela N, Kozdron E, Szczypiorski P. Moderate exercise may attenuate some aspects of immunosenescence. BMC geriatrics. 2004; 4(1):1-7.
  16. Sellami M, Bragazzi NL, Aboghaba B, Elrayess MA. The impact of acute and chronic exercise on immunoglobulins and cytokines in elderly: insights from a critical review of the literature. Frontiers in Immunology. 2021; 12:631873.
  17. Woods JA, Ceddia MA, Zack MD, Lowder TW, Lu Q. Exercise training increases the näive to memory T cell ratio in old mice. Brain, behavior, and immunity. 2003; 17(5):384-92.
  18. Gustafson MP, Wheatley-Guy CM, Rosenthal AC, Gastineau DA, Katsanis E, Johnson BD, Simpson RJ. Exercise and the immune system: Taking steps to improve responses to cancer immunotherapy. Journal for ImmunoTherapy of Cancer. 2021; 9(7).
  19. Almeida PW, Gomes-Filho A, Ferreira AJ, Rodrigues CE, Dias-Peixoto MF, Russo RC, Teixeira MM, Cassali GD, Ferreira E, Santos IC, Garcia AM. Swim training suppresses tumor growth in mice. Journal of applied physiology. 2009; 107(1):261-5.
  20. Bernardes D, Oliveira-Lima OC, da Silva TV, Faraco CC, Leite HR, Juliano MA, dos Santos DM, Bethea JR, Brambilla R, Orian JM, Arantes RM. Differential brain and spinal cord cytokine and BDNF levels in experimental autoimmune encephalomyelitis are modulated by prior and regular exercise. Journal of neuroimmunology. 2013; 264(1-2):24-34.
  21. Deforges S, Branchu J, Biondi O, Grondard C, Pariset C, Lécolle S, Lopes P, Vidal PP, Chanoine C, Charbonnier F. Motoneuron survival is promoted by specific exercise in a mouse model of amyotrophic lateral sclerosis. The Journal of physiology. 2009; 587(14):3561-72.
  22. Goes AT, Souza LC, Del Fabbro L, De Gomes MG, Boeira SP, Jesse CR. Neuroprotective effects of swimming training in a mouse model of Parkinson’s disease induced by 6-hydroxydopamine. Neuroscience. 2014; 256:61-71.
  23. Campbell JP, Turner JE. Debunking the myth of exercise-induced immune suppression: redefining the impact of exercise on immunological health across the lifespan. Frontiers in immunology. 2018:648.
  24. Kakanis M, Peake J, Hooper S, Gray B, Marshall-Gradisnik S. The open window of susceptibility to infection after acute exercise in healthy young male elite athletes. Journal of Science and Medicine in Sport. 2010 ; 13:e85-6.
  25. Xie Y, Li Z, Wang Y, Xue X, Ma W, Zhang Y, Wang J. Effects of moderate-versus high-intensity swimming training on inflammatory and CD4+ T cell subset profiles in experimental autoimmune encephalomyelitis mice. Journal of neuroimmunology. 2019; 328:60-7.
  26. Meneguello-Coutinho M, Caperuto E, Bacurau AV, Chamusca G, Uchida MC, Tibana RA, Pereira GB, Navalta JW, Wasinski F, Cavaglieri CR, Prestes J. Effects of dietary restriction or swimming on lymphocytes and macrophages functionality from old rats. Immunological investigations. 2014; 43(2):113-22.
  27. Morgado JP, Monteiro CP, Matias CN, Reis JF, Teles J, Laires MJ, Alves F. Long-term swimming training modifies acute immune cell response to a high-intensity session. European Journal of Applied Physiology. 2018; 118(3):573-83.
  28. Morgado JP, Matias CN, Reis JF, Curto D, Alves FB, Monteiro CP. The cellular composition of the innate and adaptive immune system is changed in blood in response to long-term swimming training. Frontiers in Physiology. 2020; 11:471.
  29. Kwon D, Hwang K, Kim Y, Lee K, Kang H, Song Y. Effects of swimming training on immune function of growing rats fed a high-fat diet. Journal of the Human-Environment System. 2005; 8(1):13-8.
  30. Park CH, Bae HY, Cheon JU. Effects of 24-week swimming program on the health related physical fitness, stress hormones and immune functions in adults with intellectual disabilities. Journal of the Korean Applied Science and Technology. 2020; 37(3):551-63.
  31. Kapilevich LV, Kironenko TA, Zakharova AN, Kabachkova AV, Orlov SN. Level of interleukins IL-6 and IL-15 in blood plasma of mice after forced swimming test. Bulletin of Experimental Biology and Medicine. 2017; 163(1):10-3.
  32. Silva RT, Castro PV, Coutinho MP, Brito AC, Bezerra MA, Moraes SR. Resistance jump training may reverse the weakened biomechanical behavior of tendons of diabetic Wistar rats. Fisioterapia e Pesquisa. 2017; 24:399-405.
  33. Altarifi AA, Kalha Z, Kana'An SF, Alfaqih MA, Alsalem MI. Effects of combined swimming exercise and non steroidal anti inflammatory drugs on inflammatory nociception in rats. Experimental and Therapeutic Medicine. 2019; 17(5):4303-11.
  34. Chen, H. Y., Kong, Y. H., & Cai, Z. M. (2005). A study on the morphologic changes of rat thymus with increasing age. Journal Medicine Theory Practical, 18(12), 1379-1382.
  35. Peeri, M., Azarbayjani, M., Akbarpour, M., & Ebrahimi, M. (2011). The effect of aerobic training on the immune system of aging men. Annals of Biological Research, 2(5), 299-304.
  36. Abd El-Kader SM, Al-Shreef FM. Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderly. African health sciences. 2018; 18(1):120-31.
  37. Bartlett DB, Duggal NA. Moderate physical activity associated with a higher naïve/memory T-cell ratio in healthy old individuals: potential role of IL15. Age and ageing. 2020; 49(3):368-73.
  38. Tylutka A, Morawin B, Gramacki A, Zembron-Lacny A. Lifestyle exercise attenuates immunosenescence; flow cytometry analysis. BMC geriatrics. 2021 21(1):1-3.
  39. de Brito-Neto JG, de Andrade MF, de Almeida VD, Paiva DC, de Morais NM, Bezerra CM, Fernandes JV, Nascimento EG, Fonseca IA, de Medeiros Fernandes TA. Strength training improves body composition, muscle strength and increases CD4+ T lymphocyte levels in people living with HIV/AIDS. Infectious disease reports. 2019 23; 11(1):7925.
  40. Alberton CL, Nunes GN, Rau DG, Bergamin M, Cavalli AS, Pinto SS. Vertical ground reaction force during a water-based exercise performed by elderly women: Equipment use effects. Research quarterly for exercise and sport. 2019; 90(4):479-86.
  41. Lee B, Kim G, Jo Y, Lee B, Shin YI, Hong C. Aquatic exercise at thermoneutral water temperature enhances antitumor immune responses. Immune network. 2019 Apr 16; 19(2).
  42. Nguyen V, Mendelsohn A, Larrick JW. Interleukin-7 and immunosenescence. Journal of immunology research. 2017; 2017.
  43. Pera A, Campos C, López N, Hassouneh F, Alonso C, Tarazona R, Solana R. Immunosenescence: implications for response to infection and vaccination in older people. Maturitas. 2015; 82(1):50-5.
  44. Yu Y, Zheng S. Research progress on immune aging and its mechanisms affecting geriatric diseases. Aging Medicine. 2019; 2(4):216-22.
  45. Silva LC, de Araújo AL, Fernandes JR, Matias MD, Silva PR, Duarte AJ, Garcez Leme LE, Benard G. Moderate and intense exercise lifestyles attenuate the effects of aging on telomere length and the survival and composition of T cell subpopulations. Age. 2016; 38(1):1-6.
  46. Fletcher JM, Vukmanovic-Stejic M, Dunne PJ, Birch KE, Cook JE, Jackson SE, Salmon M, Rustin MH, Akbar AN. Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion. The Journal of Immunology. 2005; 175(12):8218-25.
  47. Cosgrove C, Galloway SD, Neal C, Hunter AM, McFarlin BK, Spielmann G, Simpson RJ. The impact of 6-month training preparation for an Ironman triathlon on the proportions of naive, memory and senescent T cells in resting blood. European journal of applied physiology. 2012; 112:2989-98.
  48. Ohyashiki K, Umezu T, Yoshizawa SI, Ito Y, Ohyashiki M, Kawashima H, Tanaka M, Kuroda M, Ohyashiki JH. Clinical impact of down-regulated plasma miR-92a levels in non-Hodgkin's lymphoma. PloS one. 2011; 6(2):e16408.
  49. Zhang T, Brinkley TE, Liu K, Feng X, Marsh AP, Kritchevsky S, Zhou X, Nicklas BJ. Circulating MiRNAs as biomarkers of gait speed responses to aerobic exercise training in obese older adults. Aging (Albany NY). 2017; 9(3):900.
آمار
تعداد مشاهده مقاله: 265
تعداد دریافت فایل اصل مقاله: 244