Jafari, Sajjad, Dadmehr, Majid, Sharifi, Yaeghob, Manshouri, Shirin, Kamali, Monireh, Vahidi Emami, Zahra, Rasizadeh, Reyhane, Seif, Farhad. (1400). The Potential Effects of Scrophularia Striata Boiss on COVID-19. , 4(2), 69-72. doi: 10.32598/Immunoregulation.4.2.3
Sajjad Jafari; Majid Dadmehr; Yaeghob Sharifi; Shirin Manshouri; Monireh Kamali; Zahra Vahidi Emami; Reyhane Rasizadeh; Farhad Seif. "The Potential Effects of Scrophularia Striata Boiss on COVID-19". , 4, 2, 1400, 69-72. doi: 10.32598/Immunoregulation.4.2.3
Jafari, Sajjad, Dadmehr, Majid, Sharifi, Yaeghob, Manshouri, Shirin, Kamali, Monireh, Vahidi Emami, Zahra, Rasizadeh, Reyhane, Seif, Farhad. (1400). 'The Potential Effects of Scrophularia Striata Boiss on COVID-19', , 4(2), pp. 69-72. doi: 10.32598/Immunoregulation.4.2.3
Jafari, Sajjad, Dadmehr, Majid, Sharifi, Yaeghob, Manshouri, Shirin, Kamali, Monireh, Vahidi Emami, Zahra, Rasizadeh, Reyhane, Seif, Farhad. The Potential Effects of Scrophularia Striata Boiss on COVID-19. , 1400; 4(2): 69-72. doi: 10.32598/Immunoregulation.4.2.3

The Potential Effects of Scrophularia Striata Boiss on COVID-19

Immunoregulation
مقاله 2، دوره 4، شماره 2، بهار 2021، صفحه 69-72    اصل مقاله (484.96 K)
نوع مقاله: Short communication
شناسه دیجیتال (DOI): 10.32598/Immunoregulation.4.2.3
نویسندگان
Sajjad Jafari1؛ Majid Dadmehr2؛ Yaeghob Sharifi3؛ Shirin Manshouri4؛ Monireh Kamali4؛ Zahra Vahidi Emami5؛ Reyhane Rasizadeh6؛ Farhad Seif* 7
1Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
2Department of Traditional Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran.
3Department of Microbiology and Virology, School of Medicine, Urmia University of Mdicinal Sciences, Urmia, Iran.
4Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
5Department of Human Genetics, Qom Branch, Islamic Azad University, Qom, Iran.
6Department of Virology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
7Department of Immunology and Allergy, Iranian Academic Center for Education, Culture and Research, Tehran, Iran.
چکیده
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) rapidly spread worldwide. The exact mechanisms involved in the pathogenesis of Coronavirus Disease 2019 (COVID-19) are not fully understood. In addition to classical treatment, herbal medicine may effectively manage COVID-19 symptoms and supportive therapy. Scrophularia striata Boiss is a perennial herbaceous plant with immunomodulatory and anti-inflammatory properties. The extract of S. striata Boiss has revealed immunomodulatory effects on reducing T helper 2 (Th2) cytokines, including IL-4 and IL-5, that may be used to manage allergic diseases and asthma. Scrophularia striata Boiss reduces IL-4, and IL-5 may alleviate allergic diseases and asthma. The ethyl acetate extract of S. striata Boiss inhibits the production of IL-1β, TNF-α, and PGE2. Quercetin inhibits proinflammatory mediators while increasing anti-inflammatory mediators. Ethanolic extract of S. striata can significantly reduce NO production in the isolated mouse peritoneal macrophages. Moreover, S. striata Boiss has 3 essential flavonoids: quercetin, isorhamnetin-3-O-rutinoside, and nepitrin. Of them, quercetin inhibits TNF-α, IL-1β, IL-6, PGE2, COX-2, and NO, whereas increases anti-inflammatory cytokines. Therefore, S. striata Boiss is recommended for clinical trial studies in patients with COVID-19 and other viral diseases.
کلیدواژه‌ها
COVID-19؛ SARS-CoV-2؛ Scrophularia Striata Boiss؛ Cytokine؛ Quercetin
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