Zand, Nafiseh, Bozorgmehr, Mahmood, Sabetpour, Ali Reza, Naghizadeh, Mohammad Mahdi, Mirsharif, Ensieh Sadat, Ghazanfari, Tooba. (1400). No Alternation in Treg Frequency in Peripheral Blood of Chrmical Vitems With Long-term Mild-moderate Pulmonary Complication. , 4(2), 83-90. doi: 10.32598/Immunoregulation.4.2.2
Nafiseh Zand; Mahmood Bozorgmehr; Ali Reza Sabetpour; Mohammad Mahdi Naghizadeh; Ensieh Sadat Mirsharif; Tooba Ghazanfari. "No Alternation in Treg Frequency in Peripheral Blood of Chrmical Vitems With Long-term Mild-moderate Pulmonary Complication". , 4, 2, 1400, 83-90. doi: 10.32598/Immunoregulation.4.2.2
Zand, Nafiseh, Bozorgmehr, Mahmood, Sabetpour, Ali Reza, Naghizadeh, Mohammad Mahdi, Mirsharif, Ensieh Sadat, Ghazanfari, Tooba. (1400). 'No Alternation in Treg Frequency in Peripheral Blood of Chrmical Vitems With Long-term Mild-moderate Pulmonary Complication', , 4(2), pp. 83-90. doi: 10.32598/Immunoregulation.4.2.2
Zand, Nafiseh, Bozorgmehr, Mahmood, Sabetpour, Ali Reza, Naghizadeh, Mohammad Mahdi, Mirsharif, Ensieh Sadat, Ghazanfari, Tooba. No Alternation in Treg Frequency in Peripheral Blood of Chrmical Vitems With Long-term Mild-moderate Pulmonary Complication. , 1400; 4(2): 83-90. doi: 10.32598/Immunoregulation.4.2.2

No Alternation in Treg Frequency in Peripheral Blood of Chrmical Vitems With Long-term Mild-moderate Pulmonary Complication

Immunoregulation
مقاله 4، دوره 4، شماره 2، بهار 2021، صفحه 83-90    اصل مقاله (1.04 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.32598/Immunoregulation.4.2.2
نویسندگان
Nafiseh Zand1؛ Mahmood Bozorgmehr2؛ Ali Reza Sabetpour3؛ Mohammad Mahdi Naghizadeh4؛ Ensieh Sadat Mirsharif5؛ Tooba Ghazanfari* 1
1Department of Immunology, School of Medicine, Shahed University, Tehran, Iran.
2Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
3Countess of Chester Hospital, Chester, UK.
4Noncommuicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
5Immunoregulation Research Center, Shahed University, Tehran, Iran.
چکیده
Background: Regulatory T Cells (Treg) are the subgroups of lymphocytes that control inflammatory responses and regulate homeostasis processes through cellular contact and the secretion of soluble agents. We investigated the frequency of Treg in peripheral blood of sulfur mustard exposed patients with CD4, CD25, CD127, FOXP3, and CD45RA markers, compared with healthy individuals and the correlation between frequency of these cells and long-term pulmonary complications.
Materials and Methods: In total, 12 sulfur mustard exposed patients and 12 healthy volunteers were invited. Clinical inspections of both groups were performed by pulmonary specialists and spyrometric‎ evaluation that pulmonary function test operators conducted. After the isolation of peripheral blood mononuclear cells, the frequency of Treg cells was determined by flowcytometry.
Results: The frequency of Treg cells was not significantly different in those exposed to sulfur mustard. Furthermore, there was no significant correlation between spyrometric parameters and the frequency of these cells.
Conclusion: According to the current study data, there is no difference in the frequency of Treg cells between exposed patients with mild pulmonary complications and healthy volunteers. Thus, further studies are required to understand the role of these cells in the severity of pulmonary complications of these patients.
کلیدواژه‌ها
Regulatory T cells؛ Sulfur mustard؛ Bioterrorism؛ Chemical warfare
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