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Gaeini, Amirhossein, Hajighasemi, Fatemeh. (1397). Sensitivity of Human Leukemic Cells to Carvedilol. , 7(1), 37-42. doi: 10.22070/jbcp.2019.4090.1109
Amirhossein Gaeini; Fatemeh Hajighasemi. "Sensitivity of Human Leukemic Cells to Carvedilol". , 7, 1, 1397, 37-42. doi: 10.22070/jbcp.2019.4090.1109
Gaeini, Amirhossein, Hajighasemi, Fatemeh. (1397). 'Sensitivity of Human Leukemic Cells to Carvedilol', , 7(1), pp. 37-42. doi: 10.22070/jbcp.2019.4090.1109
Gaeini, Amirhossein, Hajighasemi, Fatemeh. Sensitivity of Human Leukemic Cells to Carvedilol. , 1397; 7(1): 37-42. doi: 10.22070/jbcp.2019.4090.1109

Sensitivity of Human Leukemic Cells to Carvedilol

Journal of Basic and Clinical Pathophysiology
مقاله 6، دوره 7، شماره 1، خرداد 2019، صفحه 37-42    اصل مقاله (495.21 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22070/jbcp.2019.4090.1109
نویسندگان
Amirhossein Gaeini؛ Fatemeh Hajighasemi*
Department of Immunology, Faculty of Medicine, Shahed University, Tehran, Iran
چکیده
Background and Objective: Carvedilol, a non-specific β-blocker, has been used for treatment of hypertension, stroke and congestive heart failure. The therapeutic effects of β blockers in cancer patients have been shown. Carvedilol has considerable anti-inflammatory, anti-tumor and anti-angiogenic properties. In this study, the effects of carvedilol on proliferation of human U937 and Molt-4 leukemic cells were studied in vitro.
Materials and Methods: Human leukemic T cells [Molt-4] and monocytes [U937] were cultured in Roswell Park Memorial Institute (RPMI) 1640 complete medium and were treated with different concentrations of carvedilol (1, 5, 10, 20, 50 and 100 μg/ml) for 24, 48 and 72 hours. The cytotoxicity of carvedilol on U937 and Molt-4 cells was determined using MTT (3-[4, 5 dimethylthiazol-2-yl]-2, 5-diphenyl tetrazolium bromide) assay.
Results: Carvedilol significantly decreased human U937 and Molt-4 leukemic cells proliferation, concentration- and time-dependently in comparison with control cells.
Conclusion: According to our results, carvedilol has anti-proliferative effect on U937 and Molt-4 leukemic cells in a concentration- and time-dependent manner. Thus, carvedilol might be a useful candidate for treatment of leukemic patients as well as other cancers.
کلیدواژه‌ها
Carvedilol؛ U937؛ Molt-4؛ Sensitivity
سایر فایل های مرتبط با مقاله
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