سامانه مدیریت نشریات علمی دانشگاه شاهد

Arab, Mansour, Pourpak, Zahra, Mohammadian, Sajedeh, Zare, Ahad, Shakiba, Yadollah, Shokouhi Shoormasti, Raheleh, Jalili, Mahdi, Fazlollahi, Mohammad Reza, Moin, Mostafa, Nourizadeh, Maryam. (1398). The Frequency of Human Leukocyte Antigen Class I and II Alleles and the Relationship Between Haplotypes in Gilaks Population of Iran. , 2(1), 57-66. doi: 10.32598/Immunoregulation.1.3.175
Mansour Arab; Zahra Pourpak; Sajedeh Mohammadian; Ahad Zare; Yadollah Shakiba; Raheleh Shokouhi Shoormasti; Mahdi Jalili; Mohammad Reza Fazlollahi; Mostafa Moin; Maryam Nourizadeh. "The Frequency of Human Leukocyte Antigen Class I and II Alleles and the Relationship Between Haplotypes in Gilaks Population of Iran". , 2, 1, 1398, 57-66. doi: 10.32598/Immunoregulation.1.3.175
Arab, Mansour, Pourpak, Zahra, Mohammadian, Sajedeh, Zare, Ahad, Shakiba, Yadollah, Shokouhi Shoormasti, Raheleh, Jalili, Mahdi, Fazlollahi, Mohammad Reza, Moin, Mostafa, Nourizadeh, Maryam. (1398). 'The Frequency of Human Leukocyte Antigen Class I and II Alleles and the Relationship Between Haplotypes in Gilaks Population of Iran', , 2(1), pp. 57-66. doi: 10.32598/Immunoregulation.1.3.175
Arab, Mansour, Pourpak, Zahra, Mohammadian, Sajedeh, Zare, Ahad, Shakiba, Yadollah, Shokouhi Shoormasti, Raheleh, Jalili, Mahdi, Fazlollahi, Mohammad Reza, Moin, Mostafa, Nourizadeh, Maryam. The Frequency of Human Leukocyte Antigen Class I and II Alleles and the Relationship Between Haplotypes in Gilaks Population of Iran. , 1398; 2(1): 57-66. doi: 10.32598/Immunoregulation.1.3.175

The Frequency of Human Leukocyte Antigen Class I and II Alleles and the Relationship Between Haplotypes in Gilaks Population of Iran

Immunoregulation
مقاله 8، دوره 2، شماره 1 - شماره پیاپی 3، مهر 2019، صفحه 57-66    اصل مقاله (992.48 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.32598/Immunoregulation.1.3.175
نویسندگان
Mansour Arab1؛ Zahra Pourpak1؛ Sajedeh Mohammadian1؛ Ahad Zare2؛ Yadollah Shakiba3؛ Raheleh Shokouhi Shoormasti1؛ Mahdi Jalili4؛ Mohammad Reza Fazlollahi1؛ Mostafa Moin1؛ Maryam Nourizadeh* 5
1Immunology Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
2Department of Microbiology and Immunology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
3Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
4Hematology Oncology and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
5department of immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: The Human Leukocyte Antigen (HLA) is the most polymorphic region in human genome. Moreover, HLA haplotype frequencies are largely used in transplantation, the treatment of autoimmune diseases, and population-based studies. The present study aimed to determine HLA-A, -B, -DR alleles and haplotype frequencies in 88 unrelated donors of Iranian Gilak ethnic group, by Polymerase Chain Reaction with Sequence-Specific Primer (PCR-SSP) assay. The study findings were compared with previous reports on HLA alleles of different Iranian ethnics.
Materials and Methods: The blood samples were collected from 88 donors of the Gilak ethnicity. Deoxyribonucleic Acid (DNA) of the samples were extracted. Then, we performed PCR and electrophoresis. The frequency of different alleles was analyzed using software.
Results: Our obtained results suggested that the most frequent alleles for HLA-A were A*02 (24.4%), A*11 (17.6%), and A*03 (14.2%), and the same for HLA-B were B*35 (26.7%), B*51 (12.5%), and B*52 (11.4%), and for HLA-DRB1 were DRB1*11 (14.1%), DRB1*01 (13.5%), and DRB1*04 (11.8%). In addition, the most common three-locus haplotypes were A02:B35:DRB01 (9.1%), A68:B49:DRB14 (6.2%), and A11:B51:DRB04 (5.1%) among the studied group.
Conclusion: Despite some differences, we found a strong relationship in the allelic variation between Gilak ethnicity and other Iranian and Caucasians ethnics.
کلیدواژه‌ها
Human Leukocyte Antigen؛ Classes I and II؛ Gilak ethnicity؛ Gilan Province
مراجع

Hajjej A, Almawi WY, Arnaiz Villena A, Hattab L, Hmida S. The genetic heterogeneity of Arab populations as inferred from HLA genes. PLOS One. 2018; 13(3):e0192269. [DOI:10.1371/journal.pone.0192269] [PMID] [PMCID]
Nikbin B, Nicknam MH, Hadinedoushan H, Ansaripour B, Moradi B, Yekaninejad M, et al. Human Leukocyte Antigen (HLA) class I and II polymorphism in Iranian healthy population from Yazd Province. Iranian Journal of Allergy, Asthma and Immunology. 2017; 16(1):1-13. [PMID]
Rubinstein P, Rosenfeld R, Adamson JW, Stevens CE. Stored placental blood for unrelated bone marrow reconstitution. Blood Journal. 1993; 81(7):1679-90. [PMID]
Esmaeili A, Rabe SZT, Mahmoudi M, Rastin M. Frequencies of HLA-A, B and DRB1 alleles in a large normal population living in the city of Mashhad, Northeastern Iran. Iranian Journal of Basic Medical Sciences. 2017; 20(8):940-3. [PMID] [PMCID]
Shaiegan M, Yari F, Abolghasemi H, Bagheri N, Paridar M, Heidari A, et al. Allele frequencies of HLA-A, B and DRB1 among people of Fars ethnicity living in Tehran. Iranian Journal of Blood and Cancer. 2011; 3(4):55-9.
Amirzargar A, Mytilineos J, Farjadian S, Doroudchi M, Scherer S, Opelz G, et al. Human Leukocyte Antigen class II allele frequencies and haplotype association in Iranian normal population. Human Immunology. 2001; 62(11):1234-8. [DOI:10.1016/S0198-8859(01)00320-2]
Farjadian S, Moqadam F, Ghaderi A. HLA class II gene polymorphism in Parsees and Zoroastrians of Iran. International Journal of Immunogenetics. 2006; 33(3):185-91. [DOI:10.1111/j.1744-313X.2006.00594.x] [PMID]
Shahsavar F, Varzi AM, Ahmadi SAY. A genomic study on distribution of Human Leukocyte Antigen (HLA)-A and HLA-B alleles in Lak population of Iran. Genomics Data. 2017; 11:3-6. [DOI:10.1016/j.gdata.2016.11.012] [PMID] [PMCID]
Farjadian S, Naruse T, Kawata H, Ghaderi A, Bahram S, Inoko H. Molecular analysis of HLA allele frequencies and haplotypes in Baloch of Iran compared with related populations of Pakistan. Tissue Antigens. 2004; 64(5):581-7. [DOI:10.1111/j.1399-0039.2004.00302.x] [PMID]
Sayad A, Akbari MT, Mehdizadeh M, Movafagh A, Hajifathali A. The association of HLA-Class I and class II with Hodgkin’s Lymphoma in Iranian Patients. BioMed Research International. 2014; 2014(231236):1-5. [DOI: 10.1155/2014/231236] [PMID] [PMCID]
Khazaei H, Aghamohammadi A, Rezaei N, Nikbin B, Khosravi M, MiriMoghaddam I. Major histocompatibility complex class I and II antigens frequencies in Baloch ethnic group living in the southeast region of Iran. Transplantation Proceedings; 2004; 36(5):1302-4. [DOI:10.1016/j.transproceed.2004.05.061]
Farjadian S, Ota M, Inoko H, Ghaderi A. The genetic relationship among Iranian ethnic groups: An anthropological view based on HLA class II gene polymorphism. Molecular Biology Reports. 2009; 36(7):1943. [DOI:10.1007/s11033-008-9403-4] [PMID]
Sarafnejad A, Khosravi F, Alimoghadam K, Dianat S, Ansaripour B, Moradi B, et al. HLA class II allele and haplotype frequencies in Iranian patients with acute myelogenous leukemia and control group. Iranian Journal of Allergy, Asthma and Immunology. 2006; 5(3):115-20. [PMID]
Khosravi F, Amirzargar A, Sarafnejad A, Nicknam MH, Alimoghadam K, Dianat S, et al. HLA class II allele and haplotype frequencies in Iranian patients with leukemia. Iranian Journal of Allergy, Asthma and Immunology. 2007; 6(3):137-42. [PMID]
Amanzadeh A, Amirzargar AA, Mohseni N, Arjang Z, Aghamohammadi A, Shokrgozar MA, et al. Association of HLA-DRB1, DQA1 and DQB1 alleles and haplotypes with common variable immunodeficiency in Iranian patients. Avicenna Journal of Medical Biotechnology. 2012; 4(2):103-12. [PMID] [PMCID]
Mohyuddin A, Mehdi S. HLA analysis of the Parsi (Zoroastrian) population in Pakistan. Tissue Antigens. 2005; 66(6):691-5. [DOI:10.1111/j.1399-0039.2005.00507.x] [PMID]
Piancatelli D, Canossi A, Aureli A, Oumhani K, Del Beato T, Di Rocco M, et al. Human Leukocyte Antigen -A, -B, and‐Cw polymorphism in a Berber population from North Morocco using sequence‐based typing. Tissue Antigens. 2004; 63(2):158-72. [DOI:10.1111/j.1399-0039.2004.00161.x] [PMID]
Farjadian S, Ghaderi A. Iranian Lurs genetic diversity: An anthropological view based on HLA class II profiles. Iranian Journal of Immunology. 2006; 3(3):106-13. [PMID]
Arnaiz Villena A, Benmamar D, Alvarez M, Diaz Campos N, Varela P, Gomez Casado E, et al. HLA allele and haplotype frequencies in Algerians: Relatedness to Spaniards and Basques. Human Immunology. 1995; 43(4):259-68. [DOI:10.1016/0198-8859(95)00024-X]
Arnaiz Villena A, Iliakis P, González Hevilla M, Longás J, Gómez Casado E, Sfyridaki K, et al. The origin of Cretan populations as determined by characterization of HLA alleles. Tissue Antigens. 1999; 53(3):213-26. [DOI:10.1034/j.1399-0039.1999.530301.x] [PMID]
Jazairi B, Khansaa I, Ikhtiar A, Murad H. Frequency of HLA-DRB1 and HLA-DQB1 alleles and haplotype association in Syrian population. Immunological Investigations. 2016; 45(2):172-9. [DOI:10.3109/08820139.2015.1131293] [PMID]
Madsen M, Graugaard B, Lamm L, Josrgensen F, Kissmeyer Nielsen F. HLA-DR genes and antigens in the Danish population. A study of 500 unrelated Danes. Tissue Antigens. 1981; 18(4):258-69. [DOI:10.1111/j.1399-0039.1981.tb01390.x] [PMID]
Rønningen KS, Spurkland A, Markussen G, Iwe T, Vartdal F, Thorsby E. Distribution of HLA class II alleles among Norwegian Caucasians. Human Immunology. 1990; 29(4):275-81. [DOI:10.1016/0198-8859(90)90041-M]
Wang FQ, Semana G, Fauchst R, Genetet B. HLA-DR and -DQ genotyping by PCR-SSO in shanghai Chinese. Tissue Antigens. 1993; 41(5):223-6. [DOI:10.1111/j.1399-0039.1993.tb02010.x] [PMID]
Hashimoto M, Kinoshita T, Yamasaki M, Tanaka H, Imanishi T, Ihara H, et al. Gene frequencies and Haplotypic Associations within the HLA region in 916 unrelated Japanese individuals. Tissue Antigens. 1994; 44(3):166-73. [DOI:10.1111/j.1399-0039.1994.tb02375.x] [PMID]
Ivanova R, Naoumova E, Lepage V, Djoulah S, Yordanov Y, Loste M, et al. HLA-DRB1, DQA1, DQB1 DNA polymorphism in the Bulgarian population. Tissue Antigens. 1996; 47(2):122-6. [DOI:10.1111/j.1399-0039.1996.tb02524.x] [PMID]
Grubić Z, Ẑunec R, Naipal A, Kaŝtelan A, Giphart M. Molecular analysis of HLA class II polymorphism in Croatians. Tissue Antigens. 1995; 46(4):293-8. [DOI:10.1111/j.1399-0039.1995.tb02495.x] [PMID]
Martinez Laso J, De Juan D, Martinez Quiles N, Gomez Casado E, Cuadrado E, Arnaiz Villena A. The contribution of the HLA-A, -B, -C and -DR, -DQ DNA typing to the study of the origins of Spaniards and Basques. Tissue Antigens. 1995; 45(4):237-45. [DOI:10.1111/j.1399-0039.1995.tb02446.x] [PMID]
Arnaiz Villena A, Martínez Laso J, Gómez Casado E, Díaz Campos N, Santos P, Martinho A, et al. Relatedness among Basques, Portuguese, Spaniards, and Algerians studied by HLA allelic frequencies and haplotypes. Immunogenetics. 1997; 47(1):37-43. [DOI:10.1007/s002510050324] [PMID]
Rani R, Fernandez Vina M, Stastny P. Associations between HLA class II alleles in a North Indian population. Tissue Antigens. 1998; 52(1):37-43. [DOI:10.1111/j.1399-0039.1998.tb03021.x] [PMID]
Hill JA, Southwood S, Sette A, Jevnikar AM, Bell DA, Cairns E. Cutting edge: The conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1* 0401 MHC class II molecule. The Journal of Immunology. 2003; 171(2):538-41. [DOI:10.4049/jimmunol.171.2.538] [PMID]

آمار
تعداد مشاهده مقاله: 1,064
تعداد دریافت فایل اصل مقاله: 913