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Babaie, Delara, Nabavi, Mohammad, Arshi, Saba, Gorjipour, Houshang, Darougar, Sepideh. (1398). The Relationship Between Serum Interleukin-6 Level and Chronic Urticaria. , 2(1), 41-46. doi: 10.32598/Immunoregulation.1.3.159
Delara Babaie; Mohammad Nabavi; Saba Arshi; Houshang Gorjipour; Sepideh Darougar. "The Relationship Between Serum Interleukin-6 Level and Chronic Urticaria". , 2, 1, 1398, 41-46. doi: 10.32598/Immunoregulation.1.3.159
Babaie, Delara, Nabavi, Mohammad, Arshi, Saba, Gorjipour, Houshang, Darougar, Sepideh. (1398). 'The Relationship Between Serum Interleukin-6 Level and Chronic Urticaria', , 2(1), pp. 41-46. doi: 10.32598/Immunoregulation.1.3.159
Babaie, Delara, Nabavi, Mohammad, Arshi, Saba, Gorjipour, Houshang, Darougar, Sepideh. The Relationship Between Serum Interleukin-6 Level and Chronic Urticaria. , 1398; 2(1): 41-46. doi: 10.32598/Immunoregulation.1.3.159

The Relationship Between Serum Interleukin-6 Level and Chronic Urticaria

Immunoregulation
مقاله 6، دوره 2، شماره 1 - شماره پیاپی 3، مهر 2019، صفحه 41-46    اصل مقاله (529.77 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.32598/Immunoregulation.1.3.159
نویسندگان
Delara Babaie1؛ Mohammad Nabavi2؛ Saba Arshi2؛ Houshang Gorjipour3؛ Sepideh Darougar* 4
1Department of Allergy and Clinical Immunology, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2Department of Allergy, Hazrat Rasul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
3Department of Allergy and Clinical Immunology, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran.
4Department of Allergy and Clinical Immunology, Faculty of Medicine, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.
چکیده
Background: The immunologic profile of chronic urticaria is not only important for diagnostic purposes, but also for therapeutic approaches. This study evaluated the serum levels of Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF-α) and Interferon-ϒ (IFN-ϒ) in patients with chronic urticaria to find a biomarker.
Materials and Methods: Forty-one patients with chronic urticaria referring to the Allergy Outpatient Clinic of Rasoul Akram Hospital and 20 healthy control subjects were enrolled in the study. A questionnaire was filled and the disease activity score was determined in a one-week period for every patient. All patients underwent basic laboratory tests in addition to the Autologous Serum Skin Test. Their serum IL-6, TNF-α, and IFN-ϒ levels were also evaluated.
Results: The patients were divided into two groups comprising of 20 and 21 participants according to the results of Autologous Serum Skin Tests. The serum IL-6 levels were elevated in the patients’ group (P=0.015). However, there was no significant difference between the patients with chronic urticaria and healthy controls in the serum levels of TNF-α (P=0.25), and IFN-ϒ (P=0.55), neither in the exact state nor by the Mann-Whitney U test.
Conclusion: Serum IL-6 level was elevated in patients with chronic urticaria, but the serum levels of IFN-ϒ and TNF-α were not significantly elevated.
کلیدواژه‌ها
Chronic urticaria؛ Cytokine؛ Interleukin-6 (IL-6)؛ Tumor Necrosis Factor-α (TNF-α)؛ Interferon-ϒ (IFN-ϒ)
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