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Yousofi Darani, Hossein, Jafaei Nodeh, Fereshteh, Ramazaninia, Seyedeh Tala, Sharafi, Seyedeh Maryam. (1397). Effect of Immune Responses Against Hydatid Cyst Antigens on Growth of Melanoma Tumor. , 1(2), 107-112. doi: 10.32598/Immunoregulation.1.2.101
Hossein Yousofi Darani; Fereshteh Jafaei Nodeh; Seyedeh Tala Ramazaninia; Seyedeh Maryam Sharafi. "Effect of Immune Responses Against Hydatid Cyst Antigens on Growth of Melanoma Tumor". , 1, 2, 1397, 107-112. doi: 10.32598/Immunoregulation.1.2.101
Yousofi Darani, Hossein, Jafaei Nodeh, Fereshteh, Ramazaninia, Seyedeh Tala, Sharafi, Seyedeh Maryam. (1397). 'Effect of Immune Responses Against Hydatid Cyst Antigens on Growth of Melanoma Tumor', , 1(2), pp. 107-112. doi: 10.32598/Immunoregulation.1.2.101
Yousofi Darani, Hossein, Jafaei Nodeh, Fereshteh, Ramazaninia, Seyedeh Tala, Sharafi, Seyedeh Maryam. Effect of Immune Responses Against Hydatid Cyst Antigens on Growth of Melanoma Tumor. , 1397; 1(2): 107-112. doi: 10.32598/Immunoregulation.1.2.101

Effect of Immune Responses Against Hydatid Cyst Antigens on Growth of Melanoma Tumor

Immunoregulation
مقاله 7، دوره 1، شماره 2، فروردین 2019، صفحه 107-112    اصل مقاله (541.25 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.32598/Immunoregulation.1.2.101
نویسندگان
Hossein Yousofi Darani1؛ Fereshteh Jafaei Nodeh2؛ Seyedeh Tala Ramazaninia2؛ Seyedeh Maryam Sharafi* 3
1Cancer Prevention Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
2Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
3Environment Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
چکیده
Background: Hydatid cyst is the larval stage of the tape worm parasite, Echinococcus granulosus. Human is infected by ingestion of parasite ova excreted in dog feces. The anticancer activity of different antigens of hydatid cyst has been reported in the previous works. In this research, the role of immune system in induction of this anticancer activity has been investigated.
Materials and Methods: Spleen cells of mice immunized with hydatid cyst antigens were transferred to the recipient mice that had already been challenged with melanoma cells. Also, mice with melanoma cancer were injected with antisera raised against hydatid cyst antigens. In all above mice, tumor growth was measured using a caliper.
Results: Passive transfer of spleen cells resulted in significant inhibition of melanoma cancer growth. However passive transfer of antisera did not affect cancer growth in the recipient mice.
Conclusion: According to the results of this work, cellular immunity but not humoral immunity may be involved in induction of anticancer activities of hydatid cyst.
کلیدواژه‌ها
Hydatid cyst؛ Cellular immunity؛ Humoral immunity؛ Melanoma
مراجع

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