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Aghajani, Marjan, Vaez Mahdavi, Mohammad Reza, Khalili Najafabadi, Mohsen, Ghazanfari, Tooba, Kazemi Moghaddam, Ehsan. (1397). Effects of Social Stresses on Immune Response in Female and Male Mice. , 1(2), 101-106. doi: 10.32598/Immunoregulation.1.2.95
Marjan Aghajani; Mohammad Reza Vaez Mahdavi; Mohsen Khalili Najafabadi; Tooba Ghazanfari; Ehsan Kazemi Moghaddam. "Effects of Social Stresses on Immune Response in Female and Male Mice". , 1, 2, 1397, 101-106. doi: 10.32598/Immunoregulation.1.2.95
Aghajani, Marjan, Vaez Mahdavi, Mohammad Reza, Khalili Najafabadi, Mohsen, Ghazanfari, Tooba, Kazemi Moghaddam, Ehsan. (1397). 'Effects of Social Stresses on Immune Response in Female and Male Mice', , 1(2), pp. 101-106. doi: 10.32598/Immunoregulation.1.2.95
Aghajani, Marjan, Vaez Mahdavi, Mohammad Reza, Khalili Najafabadi, Mohsen, Ghazanfari, Tooba, Kazemi Moghaddam, Ehsan. Effects of Social Stresses on Immune Response in Female and Male Mice. , 1397; 1(2): 101-106. doi: 10.32598/Immunoregulation.1.2.95

Effects of Social Stresses on Immune Response in Female and Male Mice

Immunoregulation
مقاله 6، دوره 1، شماره 2، فروردین 2019، صفحه 101-106    اصل مقاله (533.98 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.32598/Immunoregulation.1.2.95
نویسندگان
Marjan Aghajani1؛ Mohammad Reza Vaez Mahdavi* 2؛ Mohsen Khalili Najafabadi3؛ Tooba Ghazanfari4؛ Ehsan Kazemi Moghaddam5
1Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
2Equity and Health Research, Shahed University, Tehran, Iran.
3Department of Physiology, Faculty of Medicine, Shahed University, Tehran, Iran.
4Immunoregulation Research Center, Shahed University, Tehran, Iran.
5Shiraz Burn and Wound Healing Research Center, Amir-al-Momenin Burn Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Background: Social stress is a factor involved in the etiology of many diseases. Also, gender is another factor which predisposes individuals to certain disease. Results from animal and human studies suggest that socially-stressed men are more vulnerable to catching diseases compared to socially-stressed women.
Materials and Methods: The role of chronic social stress and gender were examined in the present study through implementing food deprivation, food intake inequality, and unstable social status (cage-mate change every three days) for a period of 14 days on 96 male and female mice. Then, vital activity of peritoneal macrophages and spleen’s lymphocytes were measured using MTT test as well as the concentration of Tumor Necrosis Factor-alpha (TNF-α) by ELISA technique.
Results: Our results showed that cell viability of peritoneal macrophages and spleen’s lymphocytes as well as serum concentration of TNF-α in all female and male stressed animals increased compared to the controls (PConclusion: The results suggest that social factors have significant effects on immunity and should be considered in the studies of gender differences for evaluating possible effective mechanisms.
کلیدواژه‌ها
Food deprivation؛ Inequality؛ Peritoneal macrophages؛ Cellular immunity؛ Gender role؛ Tumor Necrosis Factor-alpha (TNF-α)
مراجع

Farrell C, McAvoy H, Wilde J. Tackling health inequalities: An all-Ireland approach to social determinants. Leinster: Combat Poverty Agency; 2008.
Murali V, Oyebode F. Poverty, social inequality and mental health. Advances in Psychiatric Treatment. 2004; 10(3):216-24. [DOI:10.1192/apt.10.3.216]
Kim Y, Bolortuya Y, Chen L, Basheer R, McCarley RW, Strecker RE. Decoupling of sleepiness from sleep time and intensity during chronic sleep restriction: Evidence for a role of the adenosine system. Sleep. 2012; 35(6):861-9. [DOI:10.5665/sleep.1890] [PMID] [PMCID]
Aghajani M, Mahdavi MRV, Najafabadi MK, Ghazanfari T, Azimi A, Soleymani SA, et al. Effects of dominant/subordinate social status on formalin-induced pain and changes in serum proinflammatory cytokine concentrations in mice. PloS One. 2013; 8(11):e80650. [DOI:10.1371/journal.pone.0080650] [PMID] [PMCID]
O’leary A. Stress, emotion, and human immune function. Psychological Bulletin. 1990; 108(3):363-82. [DOI:10.1037/0033-2909.108.3.363] [PMID]
Aghajani M, Mahdavi MRV, Najafabadi MK, Ghazanfari T. The effect of social stress on chronic pain perception in female and male mice. PLOS One. 2012; 7(10):e47218. [DOI:10.1371/journal.pone.0047218] [PMID] [PMCID]
Angele MK, Schwacha MG, Ayala A, Chaudry IH. Effect of gender and sex hormones on immune responses following shock. Shock. 2000; 14(2):81-90. [DOI:10.1097/00024382-200014020-00001] [PMID]
Klein SL. The effects of hormones on sex differences in infection: from genes to behavior. Neuroscience & Biobehavioral Reviews. 2000; 24(6):627-38. [DOI:10.1016/S0149-7634(00)00027-0]
Moradi F, Mahdavi V, Reza M, Ahmadiani A, Rogani M, Altiraihi T, et al. Can social instability, food deprivation and food inequality accelerate neuronal aging? Basic and Clinical Neuroscience. 2012; 3(3):38-48.
Heidary F, Mahdavi MRV, Momeni F, Minaii B, Rogani M, Fallah N, et al. Food inequality negatively impacts cardiac health in rabbits. PloS One. 2008; 3(11):e3705. [DOI:10.1371/journal.pone.0003705] [PMID] [PMCID]
Van Haasteren G, Linkels E, Van Toor H, Klootwijk W, Kaptein E, De Jong F, et al. Effects of long-term food reduction on the hypothalamus-pituitary-thyroid axis in male and female rats. Journal of Endocrinology. 1996; 150(2):169-78. [DOI:10.1677/joe.0.1500169] [PMID]
Aghajani M, Mahdavi V, Reza M, Ghazanfari T, Khalili M, Azimi A, et al. [Effects of social stress on pain behavior, immune cells and serum concentrations of TNF-α, Interleukin-1 and Interleukin-6 in female mice (Persian)]. Physiology and Pharmacology. 2012; 15(4):545-61.
Aghajani M, Mahdavi V, Reza M, Ghazanfari T, Khalili M, Azimi A, et al. [Effects of dominant/subordinate social status on pain behavior and proinflammatory cytokines in the serum of mice (Persian)]. Physiology and Pharmacology. 2013; 16(4):380-92.
Yaraee R, Ghazanfari T, Eghtedardoost M, Rajabi M, Naseri M. The effect of MS14 on innate and cellular immune responses in BALB/c mice. Immunopharmacology and Immunotoxicology. 2011; 33(3):509-14. [DOI:10.3109/08923973.2010.543687] [PMID]
Bartolomucci A, Palanza P, Gaspani L, Limiroli E, Panerai AE, Ceresini G, et al. Social status in mice: Behavioral, endocrine and immune changes are context dependent. Physiology & Behavior. 2001; 73(3):401-10. [DOI:10.1016/S0031-9384(01)00453-X]
Segerstrom SC, Miller GE. Psychological stress and the human immune system: A meta-analytic study of 30 years of inquiry. Psychological Bulletin. 2004; 130(4):601. [DOI:10.1037/0033-2909.130.4.601] [PMID] [PMCID]
Sapolsky RM. Social status and health in humans and other animals. Annual Review of Anthropology. 2004; 33:393-418. [DOI:10.1146/annurev.anthro.33.070203.144000]
Klein F, Lemaire V, Sandi C, Vitiello S, Van der Logt J, Laurent PE, et al. Prolonged increase of corticosterone secretion by chronic social stress does not necessarily impair immune funnctions. Life Sciences. 1992; 50(10):723-31. [DOI:10.1016/0024-3205(92)90475-5]
Avitsur R, Padgett DA, Dhabhar FS, Stark JL, Kramer KA, Engler H, et al. Expression of glucocorticoid resistance following social stress requires a second signal. Journal of Leukocyte Biology. 2003; 74(4):507-13. [DOI:10.1189/jlb.0303090] [PMID]
Johnson R, Storts R, Welsh T, Welsh C, Meagher M. Social stress alters the severity of acute Theiler’s virus infection. Journal of Neuroimmunology. 2004; 148(1):74-85. [DOI:10.1016/j.jneuroim.2003.11.009] [PMID]
Avitsur R, Kavelaars A, Heijnen C, Sheridan JF. Social stress and the regulation of tumor necrosis factor-α secretion. Brain, Behavior, and Immunity. 2005; 19(4):311-7. [DOI:10.1016/j.bbi.2004.09.005] [PMID]
Meagher MW, Welch C. Cytokines Mediate the adverse effects of social stress in an animal mdel of Multiple Sclerosis. Psychological Science. 2008; 22:1-5.
Sapolsky RM. The influence of social hierarchy on primate health. Science. 2005; 308(5722):648-52. [DOI:10.1126/science.1106477] [PMID]
Stefanski V, Grüner S. Gender difference in basal and stress levels of peripheral blood leukocytes in laboratory rats. Brain, Behavior, and Immunity. 2006; 20(4):369-77. [DOI:10.1016/j.bbi.2005.11.001] [PMID]
Bouman A, Schipper M, Heineman MJ, Faas MM. Gender difference in the non‐specific and specific immune response in humans. American Journal of Reproductive Immunology. 2004; 52(1):19-26. [DOI:10.1111/j.1600-0897.2004.00177.x] [PMID]

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