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Zahedi, Elham, Sanaie Rad, Ashkan, Khalili, Mohsen, esmail jamaat, elham, Salari, Spideh. (1397). The effect of electroconvulsive therapy on the levels of oxidative stress factors in the prefrontal cortex of depressed rats. , 6(2), 27-31. doi: 10.22070/jbcp.2018.3238.1097
Elham Zahedi; Ashkan Sanaie Rad; Mohsen Khalili; elham esmail jamaat; Spideh Salari. "The effect of electroconvulsive therapy on the levels of oxidative stress factors in the prefrontal cortex of depressed rats". , 6, 2, 1397, 27-31. doi: 10.22070/jbcp.2018.3238.1097
Zahedi, Elham, Sanaie Rad, Ashkan, Khalili, Mohsen, esmail jamaat, elham, Salari, Spideh. (1397). 'The effect of electroconvulsive therapy on the levels of oxidative stress factors in the prefrontal cortex of depressed rats', , 6(2), pp. 27-31. doi: 10.22070/jbcp.2018.3238.1097
Zahedi, Elham, Sanaie Rad, Ashkan, Khalili, Mohsen, esmail jamaat, elham, Salari, Spideh. The effect of electroconvulsive therapy on the levels of oxidative stress factors in the prefrontal cortex of depressed rats. , 1397; 6(2): 27-31. doi: 10.22070/jbcp.2018.3238.1097

The effect of electroconvulsive therapy on the levels of oxidative stress factors in the prefrontal cortex of depressed rats

Journal of Basic and Clinical Pathophysiology
مقاله 6، دوره 6، شماره 2، آذر 2018، صفحه 27-31    اصل مقاله (422.83 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22070/jbcp.2018.3238.1097
نویسندگان
Elham Zahedi1؛ Ashkan Sanaie Rad* 2؛ Mohsen Khalili3؛ elham esmail jamaat1؛ Spideh Salari3
1Department of Physiology, School of Medicine, Shahed University Tehran, Iran
2Department of Physiology, School of Medicine, Shahed University, Tehran, Iran
3School of Medicine, Shahed University Tehran, Iran
چکیده
Background and Objective: Electroconvulsive therapy (ECT) is one of the effective and less complicated methods for treatment of depression in cases of resistance to common treatments. Given the fundamental role of pre-frontal cortex on changing the mood of depression-related behaviors in depressed patients, the effects of electroconvulsive therapy on enzymatic activity of this cortex were taken into account in this study.
Materials and Methods: For this purpose, 42 male Wistar rats were divided into three control, depressed and ECT groups. To create depression, Chronic Unpredictable Mild Stress (CUMS) method was used. Finally, NO, MDA, GSH and SOD in prefrontal portion of the brain in three mentioned groups were measured
Results: Our findings showed a non-significant increase of MDA (p>0.05) in both groups of depress and ECT in comparison with control. ECT caused a significant increase in contents of GSH and SOD in prefrontal cortex versus the group of control. Also, ECT significantly increased the level of nitrite as compared with control.
Conclusion: Treatment of depression by ECT could increase the level of antioxidants in the depressed rats' brain and it may be considered as a treatment for moderate depression disorders.
کلیدواژه‌ها
Depression؛ Electroconvulsive therapy؛ Oxidative stress؛ Rat
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