Khalili, Mohsen, Zahedi, Elham, Narenjkar, Jamshid, Sanaie Rad, Ashkan. (1396). Ameliorative activity of co-administration of ketamine and ECT on depression like behaviors in depressed rats. , 6(1), 43-48. doi: 10.22070/jbcp.2018.3005.1091
Mohsen Khalili; Elham Zahedi; Jamshid Narenjkar; Ashkan Sanaie Rad. "Ameliorative activity of co-administration of ketamine and ECT on depression like behaviors in depressed rats". , 6, 1, 1396, 43-48. doi: 10.22070/jbcp.2018.3005.1091
Khalili, Mohsen, Zahedi, Elham, Narenjkar, Jamshid, Sanaie Rad, Ashkan. (1396). 'Ameliorative activity of co-administration of ketamine and ECT on depression like behaviors in depressed rats', , 6(1), pp. 43-48. doi: 10.22070/jbcp.2018.3005.1091
Khalili, Mohsen, Zahedi, Elham, Narenjkar, Jamshid, Sanaie Rad, Ashkan. Ameliorative activity of co-administration of ketamine and ECT on depression like behaviors in depressed rats. , 1396; 6(1): 43-48. doi: 10.22070/jbcp.2018.3005.1091

Ameliorative activity of co-administration of ketamine and ECT on depression like behaviors in depressed rats

Journal of Basic and Clinical Pathophysiology
مقاله 7، دوره 6، شماره 1، 2018، صفحه 43-48    اصل مقاله (503.85 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22070/jbcp.2018.3005.1091
نویسندگان
Mohsen Khalili1؛ Elham Zahedi* 2؛ Jamshid Narenjkar3؛ Ashkan Sanaie Rad2
1Neurophysiology Research Center, Shahed University, Tehran, Iran
2Department of Physiology, School of Medicine, Shahed University Tehran, Iran
3Department of Pharmacology, School of Medicine, Shahed University of Medical sciences, Tehran, Iran
چکیده
Background and Objective: Electroconvulsive therapy (ECT) is the end choice treatment for patients with major depressive disorder (MDD). Regarding researches that show NMDA receptor inactivation could yield the same results as anti-depressant drugs, however, the present study examined co-administration of ECT and ketamine (as NMDA antagonist) on depressed rat behaviors.  
Materials and Methods: Fifty healthy adult male Wistar rats were divided into control (normal, no treatment) and CUMS induced depressed rats. The depressed animals were subdivided into 1- ECT, 2-ketamine, and 3- ECT + ketamine and 4- no treatment. We used sucrose preference, forced swimming, open field and elevated plus maze tests for evaluation of depression-related behavioral function.
Results: Data analysis in CUMS depressed rats that treated with ketamine + ECT showed higher sucrose consumption in sucrose preference test, more immobility in forced swimming, and the vast activity in open field and plus maze tests.
Conclusion: The behavioral analysis tests show that combination therapy with ketamine and electroconvulsive could markedly reduce depression and anxiolytic behaviors than ketamine or ECT treatment alone. 
کلیدواژه‌ها
Ketamine؛ Electroconvulsive therapy؛ Depression
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