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Mousavi, Faezeh, Eidi, Akram, Khalili, Mohsen, Roghani, Mehrdad. (1396). Metformin ameliorates learning and memory deficits in streptozotocin-induced diabetic rats. , 6(1), 17-22. doi: 10.22070/jbcp.2017.2782.1085
Faezeh Mousavi; Akram Eidi; Mohsen Khalili; Mehrdad Roghani. "Metformin ameliorates learning and memory deficits in streptozotocin-induced diabetic rats". , 6, 1, 1396, 17-22. doi: 10.22070/jbcp.2017.2782.1085
Mousavi, Faezeh, Eidi, Akram, Khalili, Mohsen, Roghani, Mehrdad. (1396). 'Metformin ameliorates learning and memory deficits in streptozotocin-induced diabetic rats', , 6(1), pp. 17-22. doi: 10.22070/jbcp.2017.2782.1085
Mousavi, Faezeh, Eidi, Akram, Khalili, Mohsen, Roghani, Mehrdad. Metformin ameliorates learning and memory deficits in streptozotocin-induced diabetic rats. , 1396; 6(1): 17-22. doi: 10.22070/jbcp.2017.2782.1085

Metformin ameliorates learning and memory deficits in streptozotocin-induced diabetic rats

Journal of Basic and Clinical Pathophysiology
مقاله 3، دوره 6، شماره 1، اردیبهشت 2018، صفحه 17-22    اصل مقاله (397.52 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22070/jbcp.2017.2782.1085
نویسندگان
Faezeh Mousavi1؛ Akram Eidi1؛ Mohsen Khalili2؛ Mehrdad Roghani* 2
1Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Neurophysiology Research Center, Shahed University, Tehran, Iran
چکیده
Background and Objective: Diabetes mellitus (DM) in long-term is associated with learning and memory decline. Metformin is an anti-diabetic drug with antioxidant and memory-improving effects. Thus, this research study was conducted to assess the effect of metformin on learning and memory in diabetic rats.
Materials and Methods: In the present study, male Wistar rats (n=32) were randomly assigned to 4 groups: control, control treated with metformin (200 mg/kg), diabetic, and diabetic treated with metformin (200 mg/kg). Diabetes was induced by streptozotocin (STZ) at a dose of 60 mg/kg. Metformin was administered i.p. at a dose of 200 mg/kg one week after STZ injection for 7 weeks. Blood sample was taken from retro-orbital plexus before STZ injection and 4 and 8 weeks after STZ injection to measure blood glucose level. Passive avoidance and Y maze tests were performed to evaluate learning and memory dysfunctions.
Results: After 8 weeks, diabetic rats showed a significant cognitive decline in passive avoidance and Y maze tests that was significantly improved after metformin treatment. In addition, metformin exerted a significant hypoglycemic effect in this model of DM.
Conclusion: This study clearly showed that treatment with metformin for 7 weeks could ameliorate cognitive decline in diabetic animals and part of its beneficial effect is due to its hypoglycemic effect.
کلیدواژه‌ها
Diabetes mellitus؛ Metformin؛ Streptozotocin؛ Cognition؛ Learning and memory
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