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Mousavi, Faegheh, Haeri Rohani, Ali, Khalili, Mohsen, Roghani, Mehrdad. (1396). L-carnosine Improves Short-Term Spatial Recognition Memory and Passive Avoidance Learning and Memory in Streptozotocin-Diabetic Rats. , 5(2), 35-40. doi: 10.22070/jbcp.2017.2758.1083
Faegheh Mousavi; Ali Haeri Rohani; Mohsen Khalili; Mehrdad Roghani. "L-carnosine Improves Short-Term Spatial Recognition Memory and Passive Avoidance Learning and Memory in Streptozotocin-Diabetic Rats". , 5, 2, 1396, 35-40. doi: 10.22070/jbcp.2017.2758.1083
Mousavi, Faegheh, Haeri Rohani, Ali, Khalili, Mohsen, Roghani, Mehrdad. (1396). 'L-carnosine Improves Short-Term Spatial Recognition Memory and Passive Avoidance Learning and Memory in Streptozotocin-Diabetic Rats', , 5(2), pp. 35-40. doi: 10.22070/jbcp.2017.2758.1083
Mousavi, Faegheh, Haeri Rohani, Ali, Khalili, Mohsen, Roghani, Mehrdad. L-carnosine Improves Short-Term Spatial Recognition Memory and Passive Avoidance Learning and Memory in Streptozotocin-Diabetic Rats. , 1396; 5(2): 35-40. doi: 10.22070/jbcp.2017.2758.1083

L-carnosine Improves Short-Term Spatial Recognition Memory and Passive Avoidance Learning and Memory in Streptozotocin-Diabetic Rats

Journal of Basic and Clinical Pathophysiology
مقاله 6، دوره 5، شماره 2، تیر 2017، صفحه 35-40    اصل مقاله (340.58 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22070/jbcp.2017.2758.1083
نویسندگان
Faegheh Mousavi1؛ Ali Haeri Rohani2؛ Mohsen Khalili3؛ Mehrdad Roghani* 4
1Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Biology, Tehran University, Tehran, Iran
3department of Physiology,school of medicine,shahed university,Abdollah Zadeh street, Keshavarz Blvd,Tehran, Iran
4Shahed Univ.
چکیده
Background and Objective: Diabetes mellitus (DM) affects synaptic plasticity in the hippocampus, leading to impairments in learning and memory. L-carnosine, an endogenous dipeptide, is reported to exhibit anti-diabetic and antioxidant effects. Therefore, this study was designed to evaluate its effect on learning and memory in diabetic rats.
Materials and Methods: In the present study, male Wistar rats (n=32) were randomly divided into four groups: control, control treated with carnosine (100 mg/kg), diabetic, and diabetic treated with carnosine (100 mg/kg). Diabetes was induced by streptozotocin (STZ) at a dose of 60 mg/kg. L-carnosine was injected i.p. at a dose of 100 mg/kg one week after STZ injection for 8 weeks. Blood sample was taken from retro-orbital plexus before STZ injection and 4 and 8 weeks after STZ injection to measure blood glucose level. Passive avoidance and Y maze tests were done to assess learning and memory deficits.
Results: After 8 weeks, diabetic rats showed a significant cognitive dysfunction in passive avoidance and Y maze tests that was significantly attenuated following carnosine treatment. In addition, carnosine showed a hypoglycemic effect.
Conclusion: This study demonstrated that treatment with carnosine for 8 weeks could improve cognitive functions in diabetic condition and part of its beneficial effect is due to its reduction of blood glucose.
کلیدواژه‌ها
Diabetes mellitus؛ L-carnosine؛ Streptozotocin؛ Cognitive dysfunction؛ Memory
مراجع
1. da Costa M, Bernardi J, Costa L, Fiuza T, Brandao R, Ribeiro MF, et al. N-acetylcysteine treatment attenuates the cognitive impairment and synaptic plasticity loss induced by streptozotocin. Chemico-Biological Interactions 2017;272:37-46.
2. Zou W, Yuan J, Tang ZJ, Wei HJ, Zhu WW, Zhang P, et al. Hydrogen sulfide ameliorates cognitive dysfunction in streptozotocin-induced diabetic rats: involving suppression in hippocampal endoplasmic reticulum stress. Oncotarget 2017.
3. Kennedy JM, Zochodne DW. Impaired peripheral nerve regeneration in diabetes mellitus. Journal of the Peripheral Nervous System 2005;10(2):144-57.
4. Jin HY, Liu WJ, Park JH, Baek HS, Park TS. Effect of dipeptidyl peptidase-IV (DPP-IV) inhibitor (Vildagliptin) on peripheral nerves in streptozotocin-induced diabetic rats. Archives of Medical Research 2009;40(7):536-44.
5. Carlsson CM. Type 2 diabetes mellitus, dyslipidemia, and Alzheimer's disease. Journal of Alzheimer's Disease 2010;20(3):711-22.
6. Macpherson H, Formica M, Harris E, Daly RM. Brain functional alterations in Type 2 Diabetes - A systematic review of fMRI studies. Frontiers in Neuroendocrinology 2017.
7. Walsh EI, Shaw M, Sachdev P, Anstey KJ, Cherbuin N. Brain atrophy in ageing: Estimating effects of blood glucose levels vs. other type 2 diabetes effects. Diabetes and Metabolism 2017.
8. Hasanein P, Felehgari Z, Emamjomeh A. Preventive effects of Salvia officinalis L. against learning and memory deficit induced by diabetes in rats: Possible hypoglycaemic and antioxidant mechanisms. Neuroscience Letters 2016;622:72-7.
9. Palleria C, Leo A, Andreozzi F, Citraro R, Iannone M, Spiga R, et al. Liraglutide prevents cognitive decline in a rat model of streptozotocin-induced diabetes independently from its peripheral metabolic effects. Behavioural Brain Research 2017;321:157-69.
10. Fatemi Tabatabaei SR, Rashno M, Ghaderi S, Askaripour M. The Aqueous Extract of Portulaca Oleracea Ameliorates Neurobehavioral Dysfunction and Hyperglycemia Related to Streptozotocin-Diabetes Induced in Ovariectomized Rats. Iranian Journal of Pharmaceutical Research 2016;15(2):561-71.
11. Wang X, Zhao L. Calycosin ameliorates diabetes-induced cognitive impairments in rats by reducing oxidative stress via the PI3K/Akt/GSK-3beta signaling pathway. Biochemical and Biophysical Research Communications 2016;473(2):428-34.
12. Fried PJ, Schilberg L, Brem AK, Saxena S, Wong B, Cypess AM, et al. Humans with Type-2 Diabetes Show Abnormal Long-Term Potentiation-Like Cortical Plasticity Associated with Verbal Learning Deficits. Journal of Alzheimer's Disease 2017;55(1):89-100.
13. Tian X, Liu Y, Ren G, Yin L, Liang X, Geng T, et al. Resveratrol limits diabetes-associated cognitive decline in rats by preventing oxidative stress and inflammation and modulating hippocampal structural synaptic plasticity. Brain Research 2016;1650:1-9.
14. Ota A, Ulrih NP. An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes. Frontiers in Pharmacology 2017;8:436.
15. Quinn PJ, Boldyrev AA, Formazuyk VE. Carnosine: its properties, functions and potential therapeutic applications. Molecular Aspects of Medicine 1992;13(5):379-444.
16. Ahshin-Majd S, Zamani S, Kiamari T, Kiasalari Z, Baluchnejadmojarad T, Roghani M. Carnosine ameliorates cognitive deficits in streptozotocin-induced diabetic rats: Possible involved mechanisms. Peptides 2016;86:102-11.
17. Hisatsune T, Kaneko J, Kurashige H, Cao Y, Satsu H, Totsuka M, et al. Effect of Anserine/Carnosine Supplementation on Verbal Episodic Memory in Elderly People. Journal of Alzheimer's Disease 2016;50(1):149-59.
18. Rokicki J, Li L, Imabayashi E, Kaneko J, Hisatsune T, Matsuda H. Daily Carnosine and Anserine Supplementation Alters Verbal Episodic Memory and Resting State Network Connectivity in Healthy Elderly Adults. Frontiers in Aging Neuroscience 2015;7:219.
19. Berezin A. Metabolic memory phenomenon in diabetes mellitus: Achieving and perspectives. Diabetes & Metabolic Syndrome 2016;10(2 Suppl 1):S176-83.
20. Baluchnejadmojarad T, Kiasalari Z, Afshin-Majd S, Ghasemi Z, Roghani M. S-allyl cysteine ameliorates cognitive deficits in streptozotocin-diabetic rats via suppression of oxidative stress, inflammation, and acetylcholinesterase. European Journal of Pharmacology 2017;794:69-76.
21. Kalalian-Moghaddam H, Baluchnejadmojarad T, Roghani M, Goshadrou F, Ronaghi A. Hippocampal synaptic plasticity restoration and anti-apoptotic effect underlie berberine improvement of learning and memory in streptozotocin-diabetic rats. European Journal of Pharmacology 2013;698(1-3):259-66.
22. Hardigan T, Ward R, Ergul A. Cerebrovascular complications of diabetes: focus on cognitive dysfunction. Clinical Science (London, England: 1979) 2016;130(20):1807-22.
23. Shinohara M, Sato N. Bidirectional interactions between diabetes and Alzheimer's disease. Neurochemistry International 2017;108:296-302.
24. Testa R, Bonfigli AR, Prattichizzo F, La Sala L, De Nigris V, Ceriello A. The "Metabolic Memory" Theory and the Early Treatment of Hyperglycemia in Prevention of Diabetic Complications. Nutrients 2017;9(5).
25. Takahashi S, Nakashima Y, Toda K. Carnosine facilitates nitric oxide production in endothelial f-2 cells. Biological and Pharmaceutical Bulletin 2009;32(11):1836-9.
26. Tomonaga S, Tachibana T, Takahashi H, Sato M, Denbow DM, Furuse M. Nitric oxide involves in carnosine-induced hyperactivity in chicks. European Journal of Pharmacology 2005;524(1-3):84-8.
27. Sharifzadeh M, Ranjbar A, Hosseini A, Khanavi M. The Effect of Green Tea Extract on Oxidative Stress and Spatial Learning in Streptozotocin-diabetic Rats. Iranian Journal of Pharmaceutical Research 2017;16(1):201-9.
28. Wang M, Yan W, Liu Y, Hu H, Sun Q, Chen X, et al. Erythropoietin ameliorates diabetes-associated cognitive dysfunction in vitro and in vivo. Scientific Reports 2017;7(1):2801.
29. Rahmeier FL, Zavalhia LS, Tortorelli LS, Huf F, Gea LP, Meurer RT, et al. The effect of taurine and enriched environment on behaviour, memory and hippocampus of diabetic rats. Neuroscience Letters 2016;630:84-92.
30. Xie RX, Li DW, Liu XC, Yang MF, Fang J, Sun BL, et al. Carnosine Attenuates Brain Oxidative Stress and Apoptosis After Intracerebral Hemorrhage in Rats. Neurochemical Research 2017;42(2):541-51.
31. Zhao J, Shi L, Zhang LR. Neuroprotective effect of carnosine against salsolinol-induced Parkinson's disease. Experimental and Therapeutic Medicine 2017;14(1):664-70.

 

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