The Effect of Acute Corticosterone Administration on Retrieval of Remote and Recent Memory in the Rat | ||
| Journal of Basic and Clinical Pathophysiology | ||
| مقاله 4، دوره 5، شماره 2، تیر 2017، صفحه 21-26 اصل مقاله (539.97 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22070/jbcp.2017.2433.1081 | ||
| نویسندگان | ||
| Amir Sina Homayooni1؛ Rafie Belali1؛ Farzane Malekpour2؛ Ali Shahbazi3؛ Farnaz Nikbakht* 1 | ||
| 1Department of Physiology Iran University of Medical Sciences | ||
| 2Department of Physiology Iran university of Medical Sciences | ||
| 3Department of Neuroscience Iran University of Medical Sciences | ||
| چکیده | ||
| Background and Objective: It is well known that stress and glucocorticoid, modulate memory processing, though the result is completely dependent on the time of stress induction. This study investigated the effect of acute corticosterone administration on memory retrieval of recent and remote memory in a 4 trials/day (low- intensity learning) or 8 trials/ day (high- intensity learning) Morris water maze protocol. Materials and Methods: Sixty four adult male Wistar rats were used in this research study. Corticosterone was injected subcutaneously (3 mg/kg) 30 min before the probe trial test of Morris water maze. Control animals received the vehicle. Results: Acute corticosterone, thirty minutes before probe test led to impairment of memory retrieval phase in recent (p Conclusion: Apparently, learning enhancement was just effective for protecting deleterious effects of corticosterone in recent memory and had no effect on remote memory. Thus, acute stress may impair memory retrieval in a time-dependent manner. | ||
| کلیدواژهها | ||
| Recent memory؛ Remote memory؛ Acute stress؛ Morris water maze | ||
| مراجع | ||
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