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Jamali-raoufi, Nida, Haghani, Sobhan, Roghani, Mehrdad, Fahanik-Babaei, Javad, Baluchnejadmojarad, tourandokht. (1396). The Effect of Hepatocyte Growth Factor on Learning and Memory Abilities in a Rat Model of Kainate-Induced Epilepsy. , 5(2), 15-20. doi: 10.22070/jbcp.2017.2541.1079
Nida Jamali-raoufi; Sobhan Haghani; Mehrdad Roghani; Javad Fahanik-Babaei; tourandokht Baluchnejadmojarad. "The Effect of Hepatocyte Growth Factor on Learning and Memory Abilities in a Rat Model of Kainate-Induced Epilepsy". , 5, 2, 1396, 15-20. doi: 10.22070/jbcp.2017.2541.1079
Jamali-raoufi, Nida, Haghani, Sobhan, Roghani, Mehrdad, Fahanik-Babaei, Javad, Baluchnejadmojarad, tourandokht. (1396). 'The Effect of Hepatocyte Growth Factor on Learning and Memory Abilities in a Rat Model of Kainate-Induced Epilepsy', , 5(2), pp. 15-20. doi: 10.22070/jbcp.2017.2541.1079
Jamali-raoufi, Nida, Haghani, Sobhan, Roghani, Mehrdad, Fahanik-Babaei, Javad, Baluchnejadmojarad, tourandokht. The Effect of Hepatocyte Growth Factor on Learning and Memory Abilities in a Rat Model of Kainate-Induced Epilepsy. , 1396; 5(2): 15-20. doi: 10.22070/jbcp.2017.2541.1079

The Effect of Hepatocyte Growth Factor on Learning and Memory Abilities in a Rat Model of Kainate-Induced Epilepsy

Journal of Basic and Clinical Pathophysiology
مقاله 3، دوره 5، شماره 2، تیر 2017، صفحه 15-20    اصل مقاله (380.05 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22070/jbcp.2017.2541.1079
نویسندگان
Nida Jamali-raoufi1؛ Sobhan Haghani2؛ Mehrdad Roghani3؛ Javad Fahanik-Babaei4؛ tourandokht Baluchnejadmojarad* 5
1IUMS
2Iran Univ Med. Sci.
3Shahed Univ.
4Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5TUMS, Tehran, Iran
چکیده
Background and Objective: Epilepsy as a chronic neurological disorder causes inherent seizures and learning and memory failure. Since there is no acceptable control of seizures in some patients with the current recommended drug therapy, new medications with different mechanisms of action are needed. Here, the beneficial effect of hepatocyte growth factor (HGF) was evaluated in an experimental model of temporal lobe epilepsy in male rats.
Materials and Methods: In the present study, effects of intracerebroventricular administration of HGF (6 µg) thirty minutes before intrahippocampal injection of kainic acid (4 µg) on spontaneous seizures and learning and memory impairment were assessed in rats. As positive control group, valproic acid (200 mg/kg) was injected intraperitoneally.
Results: Behavior data showed that the kainate rats exhibited spontaneous seizures, lower spontaneous alternation score in Y-maze task (p
Conclusion: This study revealed that HGF administration to kainate-injected rats attenuates seizure scores and improves learning and memory.
کلیدواژه‌ها
Kainic acid؛ HGF؛ Passive avoidance؛ Y maze
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