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Shekarchian, Sajjad, Eghtedardoost, Marziyeh, Fakhroueian, Zahra, Yaraee, Roya. (1403). Impact of Modified ZnO Nanoparticles on Immune Response in Mouse Lung Cancer Model. , 6(1), 71-78. doi: 10.32598/Immunoregulation.6.1.4
Sajjad Shekarchian; Marziyeh Eghtedardoost; Zahra Fakhroueian; Roya Yaraee. "Impact of Modified ZnO Nanoparticles on Immune Response in Mouse Lung Cancer Model". , 6, 1, 1403, 71-78. doi: 10.32598/Immunoregulation.6.1.4
Shekarchian, Sajjad, Eghtedardoost, Marziyeh, Fakhroueian, Zahra, Yaraee, Roya. (1403). 'Impact of Modified ZnO Nanoparticles on Immune Response in Mouse Lung Cancer Model', , 6(1), pp. 71-78. doi: 10.32598/Immunoregulation.6.1.4
Shekarchian, Sajjad, Eghtedardoost, Marziyeh, Fakhroueian, Zahra, Yaraee, Roya. Impact of Modified ZnO Nanoparticles on Immune Response in Mouse Lung Cancer Model. , 1403; 6(1): 71-78. doi: 10.32598/Immunoregulation.6.1.4

Impact of Modified ZnO Nanoparticles on Immune Response in Mouse Lung Cancer Model

Immunoregulation
دوره 6، شماره 1، آبان 2023، صفحه 71-78    اصل مقاله (1.45 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.32598/Immunoregulation.6.1.4
نویسندگان
Sajjad Shekarchian1؛ Marziyeh Eghtedardoost2؛ Zahra Fakhroueian3؛ Roya Yaraee* 1
1Department of Immunology, School of Medicine, Shahed University, Tehran, Iran.
2Arena Best Diagnostics Laboratory, Tehran, Iran.
3Department of Chemical Engineering, School of Chemical Engineering, University of Tehran, Tehran, Iran.
چکیده
Background: Lung cancer, which is characterized by the presence of malignant tumors, offers a potential avenue for treatment through the use of nanomedicines. Previous in vitro studies have shown promising effects of modified zinc oxide nanoparticles on lung cancer cell lines. Accordingly, this study investigates the impact of this nanodrug on the immune response in a mouse model of lung cancer.
Materials and Methods: In this study, a mouse model of lung cancer was utilized. Various aspects, including tumor size, infiltration of CD8+ cells and the survival rate of the mice, were carefully examined. The obtained results were subsequently analyzed using the GraphPrism software, version 9.
Results: Mice treated with the nanodrug exhibited a reduction in tumor size. Additionally, there was an increase in the number of CD8+ cells infiltrating the tissue. Furthermore, the administration of the nanodrug led to improved survival rates among the mice.
Conclusion: The use of this nanodrug has shown significant efficacy in inhibiting tumor growth. Moreover, it has demonstrated potential in enhancing CD8+ cell infiltration, thereby strengthening the immune response and suppressing tumor progression. Ultimately, this nanodrug improves the survival of mice receiving treatment.
کلیدواژه‌ها
Modified zinc oxide nanodrug؛ Lung cancer؛ CD8+ cells؛ Animal model of lung cancer
آمار
تعداد مشاهده مقاله: 48
تعداد دریافت فایل اصل مقاله: 44