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Karimi, Hooman, Asghari, Ahmad, Jahandideh, Alireza, Akbari, Ghasem, Mortazavi, Pejman. (1402). Metformin improves semen profile and hormonal levels in experimental varicocele in the rat. , 11(1), 1-8. doi: 10.22070/jbcp.2023.18013.1171
Hooman Karimi; Ahmad Asghari; Alireza Jahandideh; Ghasem Akbari; Pejman Mortazavi. "Metformin improves semen profile and hormonal levels in experimental varicocele in the rat". , 11, 1, 1402, 1-8. doi: 10.22070/jbcp.2023.18013.1171
Karimi, Hooman, Asghari, Ahmad, Jahandideh, Alireza, Akbari, Ghasem, Mortazavi, Pejman. (1402). 'Metformin improves semen profile and hormonal levels in experimental varicocele in the rat', , 11(1), pp. 1-8. doi: 10.22070/jbcp.2023.18013.1171
Karimi, Hooman, Asghari, Ahmad, Jahandideh, Alireza, Akbari, Ghasem, Mortazavi, Pejman. Metformin improves semen profile and hormonal levels in experimental varicocele in the rat. , 1402; 11(1): 1-8. doi: 10.22070/jbcp.2023.18013.1171

Metformin improves semen profile and hormonal levels in experimental varicocele in the rat

Journal of Basic and Clinical Pathophysiology
دوره 11، شماره 1، شهریور 2023، صفحه 1-8    اصل مقاله (435.43 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22070/jbcp.2023.18013.1171
نویسندگان
Hooman Karimi1؛ Ahmad Asghari* 1؛ Alireza Jahandideh1؛ Ghasem Akbari1؛ Pejman Mortazavi2
1Department of Clinical Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran
چکیده
Abstract
Objective: This study aimed to determine the effect of metformin (MET) on semen profile and hormonal levels in a model of varicocele in rats.
Materials and Methods: Sixty male Wistar rats were allocated into 5 treatment groups as control and varicocele groups. In groups 3-5, varicocele animals received MET (25, 50 and 100 mg/kg) for 42 days. At the end of the study, semen evaluations and serum testosterone and luteinizing hormone and follicle stimulating hormone levels were measured.
Results: Experimental varicocele significantly decreased total sperm count and sperm motility and increased non-motile sperms compared to the control group (p<0.05). Metformin administration (50 and 100 mg/kg) significantly increased total sperm count and sperm motility and decreased non-motile sperm as compared to the varicocele group (p<0.05). In addition, experimental varicocele significantly decreased testosterone and luteinizing hormone and follicle stimulating hormone levels as compared to the control group (p<0.05). Metformin administration (50 and 100 mg/kg) significantly increased testosterone and luteinizing hormone and follicle stimulating hormone levels as compared to the varicocele group (p<0.05).
Conclusion: These results suggested that metformin has positive role against varicocele in the rat.
کلیدواژه‌ها
Metformin؛ Semen؛ Testosterone؛ Luteinizing hormone؛ Follicle stimulating hormone؛ Varicocele
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