Baluchnejadmojarad, Tourandokht, Keshtkar, Sedigheh, Roghani, Mehrdad. (1401). S-allyl cysteine, a bioactive ingredient of Allium sativum, alleviates carbon tetrachloride-induced acute renal dysfunction in the mouse. , 10(2), 30-35. doi: 10.22070/jbcp.2023.17276.1166
Tourandokht Baluchnejadmojarad; Sedigheh Keshtkar; Mehrdad Roghani. "S-allyl cysteine, a bioactive ingredient of Allium sativum, alleviates carbon tetrachloride-induced acute renal dysfunction in the mouse". , 10, 2, 1401, 30-35. doi: 10.22070/jbcp.2023.17276.1166
Baluchnejadmojarad, Tourandokht, Keshtkar, Sedigheh, Roghani, Mehrdad. (1401). 'S-allyl cysteine, a bioactive ingredient of Allium sativum, alleviates carbon tetrachloride-induced acute renal dysfunction in the mouse', , 10(2), pp. 30-35. doi: 10.22070/jbcp.2023.17276.1166
Baluchnejadmojarad, Tourandokht, Keshtkar, Sedigheh, Roghani, Mehrdad. S-allyl cysteine, a bioactive ingredient of Allium sativum, alleviates carbon tetrachloride-induced acute renal dysfunction in the mouse. , 1401; 10(2): 30-35. doi: 10.22070/jbcp.2023.17276.1166

S-allyl cysteine, a bioactive ingredient of Allium sativum, alleviates carbon tetrachloride-induced acute renal dysfunction in the mouse

Journal of Basic and Clinical Pathophysiology
دوره 10، شماره 2، اسفند 2022، صفحه 30-35    اصل مقاله (502.69 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22070/jbcp.2023.17276.1166
نویسندگان
Tourandokht Baluchnejadmojarad* 1؛ Sedigheh Keshtkar2؛ Mehrdad Roghani3
1Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2Department of Physiology, School of Medicine, Shahed University, Tehran, Iran
3Neurophysiology Research Center, Shahed University, Tehran, Iran
چکیده
Background and Objective: Kidney diseases are endangering conditions to public health. Carbon tetrachloride (CCL4)-induced model of acute kidney injury (AKI) is a reliable model for studying renal damage under different conditions. S-allyl cysteine (SAC) is a natural organosulfur compound in aged garlic extract with multiple protective effects. In this study, possible preventive effect of SAC in CCl4 model of AKI was investigated.
Materials and Methods: For induction of AKI, CCl4 (10 ml/kg body weight; 0.175% in olive oil) was intraperitoneally injected and SAC was given orally at doses of 25 or 100 mg/kg. Functional markers of kidney were determined besides renal analysis of oxidative stress and inflammatory indices.
Results: SAC pretreatment at a dose of 100 mg/kg for 1 week before CCL4 challenge significantly and markedly reduced level of blood urea nitrogen (BUN), malondialdehyde (MDA), reactive oxygen species (ROS), tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), and significantly enhanced superoxide dismutase (SOD) activity and with no significant effect on creatinine and catalase activity. In addition, such valuable effects were not observed for SAC at a dose of 25 mg/kg in CCL4-exposed group.
Conclusion: Findings of this study indicated beneficial effect of SAC subsequent to CCL4-induced kidney injury that is partly mediated through its regulation of oxidative and inflammatory events and upregulating some of the antioxidants.
کلیدواژه‌ها
Acute kidney injury؛ Carbon tetrachloride؛ S-allyl cysteine؛ Inflammation؛ Oxidative stress
مراجع
آمار
تعداد مشاهده مقاله: 415
تعداد دریافت فایل اصل مقاله: 272
آمار
تعداد نشریات18
تعداد شماره‌ها474
تعداد مقالات4,696
تعداد مشاهده مقاله5,852,226
تعداد دریافت فایل اصل مقاله4,826,100