سامانه مدیریت نشریات علمی دانشگاه شاهد

Tayanloo-Beik, Akram, Kiasalari, Zahra, Roghani, Mehrdad. (1401). Paeonol alleviates brain glucose hypometabolism in streptozotocin murine model of sporadic Alzheimer’s disease using microPET imaging. , 10(1), 45-49. doi: 10.22070/jbcp.2021.14670.1145
Akram Tayanloo-Beik; Zahra Kiasalari; Mehrdad Roghani. "Paeonol alleviates brain glucose hypometabolism in streptozotocin murine model of sporadic Alzheimer’s disease using microPET imaging". , 10, 1, 1401, 45-49. doi: 10.22070/jbcp.2021.14670.1145
Tayanloo-Beik, Akram, Kiasalari, Zahra, Roghani, Mehrdad. (1401). 'Paeonol alleviates brain glucose hypometabolism in streptozotocin murine model of sporadic Alzheimer’s disease using microPET imaging', , 10(1), pp. 45-49. doi: 10.22070/jbcp.2021.14670.1145
Tayanloo-Beik, Akram, Kiasalari, Zahra, Roghani, Mehrdad. Paeonol alleviates brain glucose hypometabolism in streptozotocin murine model of sporadic Alzheimer’s disease using microPET imaging. , 1401; 10(1): 45-49. doi: 10.22070/jbcp.2021.14670.1145

Paeonol alleviates brain glucose hypometabolism in streptozotocin murine model of sporadic Alzheimer’s disease using microPET imaging

Journal of Basic and Clinical Pathophysiology
دوره 10، شماره 1، شهریور 2022، صفحه 45-49    اصل مقاله (447.01 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22070/jbcp.2021.14670.1145
نویسندگان
Akram Tayanloo-Beik1؛ Zahra Kiasalari2؛ Mehrdad Roghani* 2
1Department of Biology, School of Basic Sciences, Shahed University, Tehran, Iran
2Neurophysiology Research Center, Shahed University, Tehran, Iran
چکیده
Background and Objective: Intracerebroventricular (ICV) injection of streptozotocin (STZ) in rodents causes a model of sporadic Alzheimer's disease (sAD) with development of insulin resistance and neuronal dysfunction. Paeonol is a phenolic agent with neuroprotective effect due to its anti-inflammatory and anti-oxidant effects. This study was conducted to assess its beneficial effect in prevention of brain glucose hypometabolism in ICV STZ rat model of sAD.
Materials and Methods: STZ (3 mg/kg) was bilaterally injected ICV on days 0 and 2 using stereotaxic surgery and paeonol was orally given at two doses of 25 (low) or 100 (high) mg/kg from day 0 (post-surgery) till day 24 post-STZ. At the end of study, positron emission tomography (PET) imaging was employed with a micro-PET scanner through tail vein injection of 18FDG and brain to background ratio (BBR) was calculated.
Results: ICV-STZ group had a significantly low BBR compared to sham group. In contrast, ICV-STZ group treated with paeonol at a dose of 100 mg/kg had a significantly higher BBR as compared to ICV-STZ group, clearly indicating attenuation of brain glucose hypometabolism. In addition, paeonol at a dose of 25 mg/kg did not significantly improve BBR in ICV-STZ group.
Conclusion: In summary, these results revealed the beneficial dose-dependent effect of paeonol in amelioration of brain glucose hypometabolism in STZ-induced model of sAD. 
کلیدواژه‌ها
Sporadic Alzheimer’s disease؛ Streptozotocin؛ Paeonol؛ Brain glucose hypometabolism؛ Positron emission tomography
مراجع
  1. Arendt T, Stieler J, Ueberham U. Is sporadic Alzheimer's disease a developmental disorder? Journal of Neurochemistry 2017;143(4):396-408.
  2. Streit WJ, Khoshbouei H, Bechmann I. The Role of Microglia in Sporadic Alzheimer's Disease. Journal of Alzheimer's Disease 2021;79(3):961-8.
  3. Zhang L, Chen C, Mak MS, Lu J, Wu Z, Chen Q, et al. Advance of sporadic Alzheimer's disease animal models. Medicinal Research Reviews 2020;40(1):431-58.
  4. Shalaby MA, Nounou HA, Deif MM. The potential value of capsaicin in modulating cognitive functions in a rat model of streptozotocin-induced Alzheimer’s disease. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery 2019;55(1):48.
  5. Shah K, Desilva S, Abbruscato T. The role of glucose transporters in brain disease: diabetes and Alzheimer’s Disease. International Journal of Molecular Sciences 2012;13(10):12629-55.
  6. Kamat PK. Streptozotocin induced Alzheimer's disease like changes and the underlying neural degeneration and regeneration mechanism. Neural Regeneration Research 2015;10(7):1050-2.
  7. Xu F, Xiao H, Liu R, Yang Y, Zhang M, Chen L, et al. Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt. Frontiers in Pharmacology 2019;10:261.
  8. Gyawali A, Krol S, Kang Y-S. Involvement of a Novel Organic Cation Transporter in Paeonol Transport Across the Blood-Brain Barrier. Biomolecules and Therapeutics (Seoul) 2019;27(3):290-301.
  9. Bouter C, Bouter Y. (18)F-FDG-PET in Mouse Models of Alzheimer's Disease. Frontiers in Medicine (Lausanne) 2019;6:71.
  10. Chételat G, Arbizu J, Barthel H, Garibotto V, Law I, Morbelli S, et al. Amyloid-PET and (18)F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias. The Lancet Neurology 2020;19(11):951-62.
  11. Rubí S, Noguera A, Tarongí S, Oporto M, García A, Vico H, et al. Concordance between brain (18)F-FDG PET and cerebrospinal fluid biomarkers in diagnosing Alzheimer's disease. Revista Española de Medicina Nuclear e Imagen Molecular (Engl Ed) 2018;37(1):3-8.
  12. Chen P, Shen Z, Wang Q, Zhang B, Zhuang Z, Lin J, et al. Reduced Cerebral Glucose Uptake in an Alzheimer’s Rat Model With Glucose-Weighted Chemical Exchange Saturation Transfer Imaging. Frontiers in Aging Neuroscience 2021;13(118).
  13. Bouter C, Henniges P, Franke TN, Irwin C, Sahlmann CO, Sichler ME, et al. 18F-FDG-PET Detects Drastic Changes in Brain Metabolism in the Tg4–42 Model of Alzheimer’s Disease. Frontiers in Aging Neuroscience. 2019;10(425).
  14. Sharma Y, Garabadu D. Ruthenium red, mitochondrial calcium uniporter inhibitor, attenuates cognitive deficits in STZ-ICV challenged experimental animals. Brain Research Bulletin 2020;164:121-35.
  15. Cason E, Treglia G, Fagioli G. Leading role of 18 F-FDG-PET imaging in early diagnosis of Alzheimer's disease: an overview. Research and Reports in Nuclear Medicine 2011;Volume 1.
  16. Adki KM, Kulkarni YA. Neuroprotective effect of paeonol in streptozotocin-induced diabetes in rats. Life Sciences 2021;271:119202.
  17. Zhao Y, Fu B, Zhang X, Zhao T, Chen L, Zhang J, et al. Paeonol pretreatment attenuates cerebral ischemic injury via upregulating expression of pAkt, Nrf2, HO-1 and ameliorating BBB permeability in mice. Brain Research Bulletin 2014;109:61-7.
  18. Zhong SZ, Ge QH, Qu R, Li Q, Ma SP. Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice. Journal of the Neurological Sciences 2009;277(1-2):58-64.
  19. Liu J, Feng L, Ma D, Zhang M, Gu J, Wang S, et al. Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. Neuroscience Letters 2013;549:63-8.
  20. Liu J, Wang S, Feng L, Ma D, Fu Q, Song Y, et al. Hypoglycemic and antioxidant activities of paeonol and its beneficial effect on diabetic encephalopathy in streptozotocin-induced diabetic rats. Journal of Medicinal Food 2013;16(7):577-86.
  21. Xu F, Xiao H, Liu R, Yang Y, Zhang M, Chen L, et al. Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt. Frontiers in Pharmacology 2019;10(261).
  22. Zhang J, Jiang M, Zhao H, Han L, Jin Y, Chen W, et al. Synthesis of Paeonol-Ozagrel Conjugate: Structure Characterization and In Vivo Anti-Ischemic Stroke potential. Frontiers in Pharmacology. 2021;11(2330).
  23. Zhu X-L, Chen J-J, Han F, Pan C, Zhuang T-T, Cai Y-F, et al. Novel antidepressant effects of Paeonol alleviate neuronal injury with concomitant alterations in BDNF, Rac1 and RhoA levels in chronic unpredictable mild stress rats. Psychopharmacology 2018;235(7):2177-91.
  24. Lin C, Lin H-Y, Chen J-H, Tseng W-P, Ko P-Y, Liu Y-S, et al. Effects of Paeonol on Anti-Neuroinflammatory Responses in Microglial Cells. International Journal of Molecular Sciences 2015;16(4):8844-60.
  25. Liu J, Feng L, Ma D, Zhang M, Gu J, Wang S, et al. Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. Neuroscience Letters 2013;549:63-8.
  26. Su S-Y, Cheng C-Y, Tsai T-H, Hsieh C-L. Paeonol Protects Memory after Ischemic Stroke via Inhibiting β-Secretase and Apoptosis. Evidence-Based Complementary and Alternative Medicine 2012;2012:932823.
آمار
تعداد مشاهده مقاله: 243
تعداد دریافت فایل اصل مقاله: 204