Tayanloo-Beik, Akram, Kiasalari, Zahra, Roghani, Mehrdad. (1401). Paeonol alleviates brain glucose hypometabolism in streptozotocin murine model of sporadic Alzheimer’s disease using microPET imaging. , 10(1), 45-49. doi: 10.22070/jbcp.2021.14670.1145
Akram Tayanloo-Beik; Zahra Kiasalari; Mehrdad Roghani. "Paeonol alleviates brain glucose hypometabolism in streptozotocin murine model of sporadic Alzheimer’s disease using microPET imaging". , 10, 1, 1401, 45-49. doi: 10.22070/jbcp.2021.14670.1145
Tayanloo-Beik, Akram, Kiasalari, Zahra, Roghani, Mehrdad. (1401). 'Paeonol alleviates brain glucose hypometabolism in streptozotocin murine model of sporadic Alzheimer’s disease using microPET imaging', , 10(1), pp. 45-49. doi: 10.22070/jbcp.2021.14670.1145
Tayanloo-Beik, Akram, Kiasalari, Zahra, Roghani, Mehrdad. Paeonol alleviates brain glucose hypometabolism in streptozotocin murine model of sporadic Alzheimer’s disease using microPET imaging. , 1401; 10(1): 45-49. doi: 10.22070/jbcp.2021.14670.1145

Paeonol alleviates brain glucose hypometabolism in streptozotocin murine model of sporadic Alzheimer’s disease using microPET imaging

Journal of Basic and Clinical Pathophysiology
دوره 10، شماره 1، شهریور 2022، صفحه 45-49    اصل مقاله (447.01 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22070/jbcp.2021.14670.1145
نویسندگان
Akram Tayanloo-Beik1؛ Zahra Kiasalari2؛ Mehrdad Roghani* 2
1Department of Biology, School of Basic Sciences, Shahed University, Tehran, Iran
2Neurophysiology Research Center, Shahed University, Tehran, Iran
چکیده
Background and Objective: Intracerebroventricular (ICV) injection of streptozotocin (STZ) in rodents causes a model of sporadic Alzheimer's disease (sAD) with development of insulin resistance and neuronal dysfunction. Paeonol is a phenolic agent with neuroprotective effect due to its anti-inflammatory and anti-oxidant effects. This study was conducted to assess its beneficial effect in prevention of brain glucose hypometabolism in ICV STZ rat model of sAD.
Materials and Methods: STZ (3 mg/kg) was bilaterally injected ICV on days 0 and 2 using stereotaxic surgery and paeonol was orally given at two doses of 25 (low) or 100 (high) mg/kg from day 0 (post-surgery) till day 24 post-STZ. At the end of study, positron emission tomography (PET) imaging was employed with a micro-PET scanner through tail vein injection of 18FDG and brain to background ratio (BBR) was calculated.
Results: ICV-STZ group had a significantly low BBR compared to sham group. In contrast, ICV-STZ group treated with paeonol at a dose of 100 mg/kg had a significantly higher BBR as compared to ICV-STZ group, clearly indicating attenuation of brain glucose hypometabolism. In addition, paeonol at a dose of 25 mg/kg did not significantly improve BBR in ICV-STZ group.
Conclusion: In summary, these results revealed the beneficial dose-dependent effect of paeonol in amelioration of brain glucose hypometabolism in STZ-induced model of sAD. 
کلیدواژه‌ها
Sporadic Alzheimer’s disease؛ Streptozotocin؛ Paeonol؛ Brain glucose hypometabolism؛ Positron emission tomography
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