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Ghofrani, Saeed, Joghataei, Mohammad-Taghi, Afshin-Majd, Siamak, Baluchnejadmojarad, Tourandokht, Roghani, Mehrdad. (1401). Crocin, a bioactive constituent of Crocus sativus, alleviates trimethyltin-induced cognitive deficits through down-regulation of hippocampal apoptosis and oxidative stress. , 10(1), 38-44. doi: 10.22070/jbcp.2022.16405.1160
Saeed Ghofrani; Mohammad-Taghi Joghataei; Siamak Afshin-Majd; Tourandokht Baluchnejadmojarad; Mehrdad Roghani. "Crocin, a bioactive constituent of Crocus sativus, alleviates trimethyltin-induced cognitive deficits through down-regulation of hippocampal apoptosis and oxidative stress". , 10, 1, 1401, 38-44. doi: 10.22070/jbcp.2022.16405.1160
Ghofrani, Saeed, Joghataei, Mohammad-Taghi, Afshin-Majd, Siamak, Baluchnejadmojarad, Tourandokht, Roghani, Mehrdad. (1401). 'Crocin, a bioactive constituent of Crocus sativus, alleviates trimethyltin-induced cognitive deficits through down-regulation of hippocampal apoptosis and oxidative stress', , 10(1), pp. 38-44. doi: 10.22070/jbcp.2022.16405.1160
Ghofrani, Saeed, Joghataei, Mohammad-Taghi, Afshin-Majd, Siamak, Baluchnejadmojarad, Tourandokht, Roghani, Mehrdad. Crocin, a bioactive constituent of Crocus sativus, alleviates trimethyltin-induced cognitive deficits through down-regulation of hippocampal apoptosis and oxidative stress. , 1401; 10(1): 38-44. doi: 10.22070/jbcp.2022.16405.1160

Crocin, a bioactive constituent of Crocus sativus, alleviates trimethyltin-induced cognitive deficits through down-regulation of hippocampal apoptosis and oxidative stress

Journal of Basic and Clinical Pathophysiology
دوره 10، شماره 1، شهریور 2022، صفحه 38-44    اصل مقاله (443.46 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22070/jbcp.2022.16405.1160
نویسندگان
Saeed Ghofrani1؛ Mohammad-Taghi Joghataei2؛ Siamak Afshin-Majd3؛ Tourandokht Baluchnejadmojarad4؛ Mehrdad Roghani* 3
1Cellular and Molecular Research Center and Department of Neuroscience, School of Advanced Technology in Medicine, Iran University of Medical Sciences, Tehran, Iran
2Department of Anatomy and Neuroscience, Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
3Neurophysiology Research Center, Shahed University, Tehran, Iran
4Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
چکیده
Background and Objective: Cognitive deficits are associated with neurodegenerative disorders including Alzheimer’s disease (AD). Trimethyltin chloride (TMT) with potent neurotoxicity is used to induce cognitive dysfunction in rodents. Crocin is the main effective component of saffron with anti-oxidant and anti-inflammatory potential. In the present study, we investigated the effect of crocin on TMT-induced cognitive dysfunction.
Materials and Methods: TMT was i.p. administered (8 mg/kg, once) and crocin was daily given p.o. 1 h after TMT for 3 weeks at doses of 10 or 50 mg/kg. Cognitive performance was assessed in different behavioral tasks. In addition, hippocampal oxidative stress and apoptosis were measured.
Results: Treatment of TMT-challenged rats with crocin (at a dose of 50 mg/kg) prevented deficits of recognition memory in Y maze, discrimination ability in novel object discrimination (NOD) test and conditional learning and memory index in passive avoidance task. Besides, crocin significantly lowered hippocampal level of ROS and improved activity of superoxide dismutase (SOD) besides ablation of apoptotic factors including caspase 3 activity and DNA fragmentation.
Conclusion: In conclusion, crocin administration could ameliorate TMT-induced cognitive dysfunction, in part through targeting hippocampal apoptosis and oxidative stress.
کلیدواژه‌ها
Crocin؛ Trimethyltin؛ Cognition؛ Neurotoxicity؛ Oxidative stress
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