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Baluchnejadmojarad, Tourandokht, Roghani, Mehrdad. (1395). The protective effect of carvacrol on kainic acid-induced model of temporal lobe epilepsy in male rat. , 4(2), 11-16. doi: 10.22070/jbcp.2016.367
Tourandokht Baluchnejadmojarad; Mehrdad Roghani. "The protective effect of carvacrol on kainic acid-induced model of temporal lobe epilepsy in male rat". , 4, 2, 1395, 11-16. doi: 10.22070/jbcp.2016.367
Baluchnejadmojarad, Tourandokht, Roghani, Mehrdad. (1395). 'The protective effect of carvacrol on kainic acid-induced model of temporal lobe epilepsy in male rat', , 4(2), pp. 11-16. doi: 10.22070/jbcp.2016.367
Baluchnejadmojarad, Tourandokht, Roghani, Mehrdad. The protective effect of carvacrol on kainic acid-induced model of temporal lobe epilepsy in male rat. , 1395; 4(2): 11-16. doi: 10.22070/jbcp.2016.367

The protective effect of carvacrol on kainic acid-induced model of temporal lobe epilepsy in male rat

Journal of Basic and Clinical Pathophysiology
مقاله 3، دوره 4، شماره 2، تیر 2016، صفحه 11-16    اصل مقاله (439.46 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22070/jbcp.2016.367
نویسندگان
Tourandokht Baluchnejadmojarad* 1؛ Mehrdad Roghani2
1TUMS, Tehran, Iran
2Shahed
چکیده
Background and Objective: Temporal lobe epilepsy (TLE) is a chronic neurological disorder with spontaneous recurrent seizures and abnormal intracranial waves. Since the role of oxidative stress in the occurrence of epilepsy is inevitable, it seems that the use of antioxidants can prevent some of the complications resulting from this disease. This study was designed to assess the protective effect of carvacrol on seizure behavior and intracranial electroencephalographic (iEEG) recordings.
Materials and Methods: In this study, male Wistar rats were randomly allocated into four groups: Sham-operated, carvacrol (10 mg/kg) pretreated-sham-operated, kainic acid (0.8 μg/μl), and carvacrol (10 mg/kg) pretreated-kainic acid. In this study, we evaluated the status epilepticus and spontaneous seizures according to Racine΄s scores and recorded iEEG for investigating the antiepileptic effect of carvacrol in kainite-injected rats.
Results: The seizures behavior (status epilepticus and spontaneous seizures) appeared in kainite-injected rats and iEEG amplitude increased as compared to sham group (pConclusion: Collectively, the results of this study indicate that carvacrol is able to prevent some of the epilepsy disease complications in an experimental model of temporal lobe epilepsy.
کلیدواژه‌ها
Carvacrol؛ Temporal lobe epilepsy؛ Kainic acid؛ Seizure
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