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Hashemi, Mahboobeh, Karami, Manizheh, Zarrindast, Mohammadreza. (1400). Effect of simultaneous injection of l-arginine in dorsal hippocampus and laterodorsal periaqueductal gray matter on morphine-induced analgesia in rat’s formalin test. , 9(1), 52-57. doi: 10.22070/jbcp.2021.14570.1144
Mahboobeh Hashemi; Manizheh Karami; Mohammadreza Zarrindast. "Effect of simultaneous injection of l-arginine in dorsal hippocampus and laterodorsal periaqueductal gray matter on morphine-induced analgesia in rat’s formalin test". , 9, 1, 1400, 52-57. doi: 10.22070/jbcp.2021.14570.1144
Hashemi, Mahboobeh, Karami, Manizheh, Zarrindast, Mohammadreza. (1400). 'Effect of simultaneous injection of l-arginine in dorsal hippocampus and laterodorsal periaqueductal gray matter on morphine-induced analgesia in rat’s formalin test', , 9(1), pp. 52-57. doi: 10.22070/jbcp.2021.14570.1144
Hashemi, Mahboobeh, Karami, Manizheh, Zarrindast, Mohammadreza. Effect of simultaneous injection of l-arginine in dorsal hippocampus and laterodorsal periaqueductal gray matter on morphine-induced analgesia in rat’s formalin test. , 1400; 9(1): 52-57. doi: 10.22070/jbcp.2021.14570.1144

Effect of simultaneous injection of l-arginine in dorsal hippocampus and laterodorsal periaqueductal gray matter on morphine-induced analgesia in rat’s formalin test

Journal of Basic and Clinical Pathophysiology
مقاله 8، دوره 9، شماره 1، مرداد 2021، صفحه 52-57    اصل مقاله (399.14 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22070/jbcp.2021.14570.1144
نویسندگان
Mahboobeh Hashemi1؛ Manizheh Karami* 1؛ Mohammadreza Zarrindast2
1Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran
2Department of Pharmacology, School of Pharmacy, Tehran University of Medical Sciences,Tehran, Iran
چکیده
Background and Objective: Injection of l-arginine, a precursor of nitric oxide, in the rat’s hippocampus or periaqueductal gray matter reduces the analgesic effect of morphine on formalin-induced pain, but the effect of simultaneous injection of the substance in both areas have not been shown as our purpose of this research.
Materials and Methods: Wistar rats were used as control, morphine, and l-arginine groups. The rats were simultaneously cannulated in two areas of the dorsal hippocampus and laterodorsal PAG. One week later, the control animals received 50 μl of 2.5% formalin in the paw of the left foot under restrainer. The morphine group 10 min before formalin received the opioid (6 mg/kg, intraperitoneally). Other groups took l-arginine (0.25-2 µg/rat) in only one area (d hippocampus or ld PAG), prior to morphine administration. The effective dose of l-arginine (0.5 µg/rat) simultaneously was injected in both areas. The findings were analyzed by analysis of variance (ANOVA) under α=0.05.
Results: Morphine induced analgesic response. Injection of NO precursor both separately and simultaneously in the two nuclei reduced morphine-induced analgesia.
Conclusion: Increasing levels of NO due to exclusive or concurrent injection of l-arginine in the areas likely antagonize the morphine response.
کلیدواژه‌ها
L-arginine؛ PAG؛ Hippocampus؛ Formalin test
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