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Khoshvaghti, Ameneh, Abtahi, Moslem. (1399). The effects of safflower (Carthamus tinctorius) extract on thyroid gland activity in rats. , 8(2), 22-27. doi: 10.22070/jbcp.2020.13367.1135
Ameneh Khoshvaghti; Moslem Abtahi. "The effects of safflower (Carthamus tinctorius) extract on thyroid gland activity in rats". , 8, 2, 1399, 22-27. doi: 10.22070/jbcp.2020.13367.1135
Khoshvaghti, Ameneh, Abtahi, Moslem. (1399). 'The effects of safflower (Carthamus tinctorius) extract on thyroid gland activity in rats', , 8(2), pp. 22-27. doi: 10.22070/jbcp.2020.13367.1135
Khoshvaghti, Ameneh, Abtahi, Moslem. The effects of safflower (Carthamus tinctorius) extract on thyroid gland activity in rats. , 1399; 8(2): 22-27. doi: 10.22070/jbcp.2020.13367.1135

The effects of safflower (Carthamus tinctorius) extract on thyroid gland activity in rats

Journal of Basic and Clinical Pathophysiology
دوره 8، شماره 2، اسفند 2020، صفحه 22-27    اصل مقاله (469.63 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22070/jbcp.2020.13367.1135
نویسندگان
Ameneh Khoshvaghti* ؛ Moslem Abtahi
Department of Clinical Sciences, Kazerun Branch, Islamic Azad University, Kazerun, Iran
چکیده
Background and Objective: Safflower (Carthamus tinctorius) has a long history in traditional medicine. It contains a wide range of useful compounds such as flavonoids. In this study, the effect of safflower extract on thyroid gland activity was investigated.
Materials and Methods: 60 male Wistar rats were studied in four groups. The negative control was left untreated while three experimental groups intra-peritoneally received 100, 200 and 300 mg/kg B.W. of safflower hydroalcoholic extract for 28 days. The serum levels of T3, T4, FT3, FT4 and TSH were measured by radioimmunoassay method on 14th and 28th days of study.   
Results: The findings showed that short-term use of the extract directly affects thyroid function as the levels of thyroid hormones are decreased significantly, whereas it has no significant effect on TSH since its mean serum concentration remained unchanged. The long-term use of this extract did not show any significant effect, confirming that during the long run, the negative feedback on the thyroid is removed and this gland becomes adapted to some effective compound (s) present in Safflower.
Conclusion: The continuous short-term use of the safflower can decrease the level of thyroid hormones temporarily, while in the long term, it does not show the same effect.  
کلیدواژه‌ها
Carthamus tinctorius؛ Thyroid hormones؛ Thyroid-stimulating hormone؛ Rats
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