سامانه مدیریت نشریات علمی دانشگاه شاهد

Vaez Mahdavi, Mohammad Reza, Kaboudanian Ardestani, Sussan, Rezaei, Arezou, Mohammadi, Saeed, Rajabnia Chenary, Maryam, Gharegozlou, Behnaz, Naghizadeh, Mohammad Mehdi, Ghazanfari, Tooba. (1398). COVID-19 Patients Suffer From DHEA-S Deficiency. , 3(2), 135-144. doi: 10.32598/Immunoregulation.3.2.5
Mohammad Reza Vaez Mahdavi; Sussan Kaboudanian Ardestani; Arezou Rezaei; Saeed Mohammadi; Maryam Rajabnia Chenary; Behnaz Gharegozlou; Mohammad Mehdi Naghizadeh; Tooba Ghazanfari. "COVID-19 Patients Suffer From DHEA-S Deficiency". , 3, 2, 1398, 135-144. doi: 10.32598/Immunoregulation.3.2.5
Vaez Mahdavi, Mohammad Reza, Kaboudanian Ardestani, Sussan, Rezaei, Arezou, Mohammadi, Saeed, Rajabnia Chenary, Maryam, Gharegozlou, Behnaz, Naghizadeh, Mohammad Mehdi, Ghazanfari, Tooba. (1398). 'COVID-19 Patients Suffer From DHEA-S Deficiency', , 3(2), pp. 135-144. doi: 10.32598/Immunoregulation.3.2.5
Vaez Mahdavi, Mohammad Reza, Kaboudanian Ardestani, Sussan, Rezaei, Arezou, Mohammadi, Saeed, Rajabnia Chenary, Maryam, Gharegozlou, Behnaz, Naghizadeh, Mohammad Mehdi, Ghazanfari, Tooba. COVID-19 Patients Suffer From DHEA-S Deficiency. , 1398; 3(2): 135-144. doi: 10.32598/Immunoregulation.3.2.5

COVID-19 Patients Suffer From DHEA-S Deficiency

Immunoregulation
دوره 3، شماره 2 - شماره پیاپی 6، فروردین 2020، صفحه 135-144    اصل مقاله (664.37 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.32598/Immunoregulation.3.2.5
نویسندگان
Mohammad Reza Vaez Mahdavi1؛ Sussan Kaboudanian Ardestani2؛ Arezou Rezaei3؛ Saeed Mohammadi4؛ Maryam Rajabnia Chenary5؛ Behnaz Gharegozlou6؛ Mohammad Mehdi Naghizadeh7؛ Tooba Ghazanfari* 8
1Department of Physiology, Faculty of Medicine, Shahed University, Tehran, Iran.
2Instiute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
3Institute of Biological Sciences, School of Biology, Damghan University, Damghan, Iran.
4Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
5Defense Health Research Center, Tehran, Iran.
6Department of Immunology, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.
7Immunoregulation Research Center, Shahed University, Tehran, Iran.
8Immunoregulation Research Center , Shahed University< Tehran, Iran.
چکیده
Background: The nervous, endocrine, and immune systems contribute to the response and dynamic adaption to various stresses. Activation of the hypothalamic-pituitary-adrenal axis has been demonstrated in various active critical illnesses. Novel Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), is a disease with age and gender disparities.
Materials and Methods: In this study, a total of 125 consecutive inpatients with COVID-19 admitted to Imam Khomeini Hospital Complex from February 12, 2020, to April 4, 2020, were enrolled. The severity of patients was classified into three subgroups based on the types of oxygen therapies. Dehydroepiandrosterone Sulfate (DHEA-S) and cortisol levels were measured in serum of inpatients with Siemens kit.
Results: While the increase in cortisol level was not significant in COVID-19 patients, the DHEA-S level and DHEA-S/cortisol ratio significantly decreased in the patients with the increase in severity of the disease.
Conclusion: We proposed that the supplementation of DHEA, the precursor of both androgens and steroids, may ameliorate adverse outcomes of COVID-19 disease and improve COVID-19 patients’ ability to survive.
کلیدواژه‌ها
COVID-19؛ DHEA-S؛ DHEA-S/cortisol؛ DHEA supplementation؛ Iran
آمار
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