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Khalili, Mohsen, Ghosian, Mohammad Hasan, Jafaryfard*, Azam, Zahedi, Elham. (1394). Effect of combination therapy with diazepam and glibenclamide on serum lipids and glucose in type 2 diabetic rats. , 4(1), 7-12. doi: 10.22070/jbcp.2016.278
Mohsen Khalili; Mohammad Hasan Ghosian; Azam Jafaryfard*; Elham Zahedi. "Effect of combination therapy with diazepam and glibenclamide on serum lipids and glucose in type 2 diabetic rats". , 4, 1, 1394, 7-12. doi: 10.22070/jbcp.2016.278
Khalili, Mohsen, Ghosian, Mohammad Hasan, Jafaryfard*, Azam, Zahedi, Elham. (1394). 'Effect of combination therapy with diazepam and glibenclamide on serum lipids and glucose in type 2 diabetic rats', , 4(1), pp. 7-12. doi: 10.22070/jbcp.2016.278
Khalili, Mohsen, Ghosian, Mohammad Hasan, Jafaryfard*, Azam, Zahedi, Elham. Effect of combination therapy with diazepam and glibenclamide on serum lipids and glucose in type 2 diabetic rats. , 1394; 4(1): 7-12. doi: 10.22070/jbcp.2016.278

Effect of combination therapy with diazepam and glibenclamide on serum lipids and glucose in type 2 diabetic rats

Journal of Basic and Clinical Pathophysiology
مقاله 2، دوره 4، شماره 1، بهمن 2015، صفحه 7-12    اصل مقاله (416.08 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22070/jbcp.2016.278
نویسندگان
Mohsen Khalili1؛ Mohammad Hasan Ghosian2؛ Azam Jafaryfard** 3؛ Elham Zahedi4
1Neurophysiology Research Center, Shahed University, Tehran, Iran
2Department of Biochemistry, School of Medicine, Shahed University, Tehran, Iran
3Medical Student, School of Medicine, Shahed University, Tehran, Iran
4M.Sc. Student, School of Medicine, Shahed University, Tehran, Iran
چکیده
Background and Objective: Several studies have found that diazepam decreases serum glucose. Meanwhile, glibenclamide is commonly used in diabetes treatment. The objective of this study was to survey the treatment impact of diazepam and glibenclamide on blood glucose and serum lipids in mice with type II diabetes.
Materials and Methods: In this study, 32 male rats were divided into four groups, i.e. diabetes, glibenclamide, diazepam and combination of glibenclamide and diazepam. Diabetes was inducted using 60 mg/kg of streptozocin injection at single dosage. Medicinal dosage was 0.285 mg/kg for glibenclamide and was 1 mg/kg for diazepam and 50 percent of above mentioned dosages for complex therapeutic dosage. Treatment was continued for 16 days after positivity of diabetes. The level of blood glucose in serum and lipid profile of the rats were surveyed at the end of the study.
Results: Therapeutic combination of diazepam and glibenclamide caused a significant reduction of serum glucose in comparison with control group at 9 and 16 days (p<0.05). Combined treatment also caused more significant increase of serum HDL and serum HDL to LDL ratio (p<0.05), while these changes were not observed in the groups that were treated using glibenclamide or diazepam, alone.
Conclusion: The combined treatment of glibenclamide and diazepam caused the improvement in controlling the serum glucose and can appropriately change the level of serum HDL in diabetic rats.
کلیدواژه‌ها
Type II Diabetes Diazepam Glibenclamide
آمار
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