Phytic Acid Mitigates Motor Asymmetry in Male Rat with Unilateral 6-Hydroxydopamine Striatal Lesion | ||
| Journal of Basic and Clinical Pathophysiology | ||
| مقاله 6، دوره 3، شماره 2، تیر 2015، صفحه 25-28 اصل مقاله (374.39 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22070/jbcp.2015.228 | ||
| نویسندگان | ||
| Batool Rahmati1؛ Mohsen Khalili1؛ Zohreh Hamoleh-Shalali2؛ Mehrdad Roghani* 1؛ Tourandokht Baluchnejadmojarad3 | ||
| 1Neurophysiology Research Center, Shahed University, Tehran, Iran | ||
| 2School of Medicine, Shahed University, Tehran, Iran | ||
| 3Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Background and Objective: Parkinson's disease (PD) is a movement disorder with debilitating symptoms. Available treatments for PD mainly include its symptomatic relief with no prevention of its progression. Due to the iron-chelating and antioxidant effect of phytic acid (PA), this study was conducted to assess its protective effect in 6-hydroxydopamine-induced model of PD in rat. Materials and Methods: Unilateral intrastriatal 6-OHDA-lesioned rats were daily pretreated with PA p.o. at a dose of 100 mg/kg for three days till 1 h pre-surgery. Apomorphine-induced rotations were counted at 1st week post-surgery. Results: A significant contralateral rotational behavior was observed in 6-OHDA-lesioned rats (pConclusion: These findings imply that pre-lesion PA treatment could attenuate motor asymmetry in experimental model of PD and this may be of benefit in lessening motor derangements in afflicted patients. | ||
| کلیدواژهها | ||
| Phytic acid؛ Parkinson’s disease؛ 6-hydroxydopamine؛ Motor asymmetry | ||
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