Curcumin Alleviates Streptozotocin-Induced Hyperalgesia in Diabetic Neuropathic Rat via Attenuation of Lipid Peroxidation and Inflammation | ||
| Journal of Basic and Clinical Pathophysiology | ||
| مقاله 4، دوره 3، شماره 2، تیر 2015، صفحه 13-18 اصل مقاله (410.33 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22070/jbcp.2015.226 | ||
| نویسندگان | ||
| Jamshid Narenjkar1؛ Zeinab Abyar2؛ Mehrdad Roghani* 3 | ||
| 1Department of Pharmacology, School of Medicine, Shahed University, Tehran, Iran | ||
| 2School of Medicine, Shahed University, Tehran, Iran | ||
| 3Neurophysiology Research Center, Shahed University, Tehran, Iran | ||
| چکیده | ||
| Background and Objective: Hyperalgesia is one of the marked clinical signs of patients with diabetes mellitus that affects their lifestyle. This study was conducted to assess the anti-nociceptive effect of chronic administration of curcumin in streptozotocin (STZ)-diabetic rats using formalin, hot tail immersion, and paw pressure tests. Materials and Methods: This study was conducted on 40 male rats that were divided into control, curcumin-treated control, diabetic, and curcumin-treated diabetic groups. The treatment groups received i.p. administration of curcumin at a dose of 50 mg/kg for 4 weeks. Finally, hyperalgesia were assessed using standard tests. Meanwhile, serum MDA and TNFa level was also measured. Results: Curcumin treatment of diabetic rats significantly reduced pain score in chronic phase of formalin test (pConclusion: Chronic administration of curcumin has anti-nociceptive property, partly via attenuation of lipid peroxidation and inflammatory processes. | ||
| کلیدواژهها | ||
| Curcumin؛ Diabetes mellitus؛ Anti-nociceptive؛ Formalin test؛ Hot tail immersion test؛ Paw pressure test؛ Lipid peroxidation؛ Inflammation | ||
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