سامانه مدیریت نشریات علمی دانشگاه شاهد

Baluchnejadmojarad, Tourandokht, Mansouri, Monireh, Nikbakht, Farnaz, Fallah, Soudabeh, Roghani, Mehrdad. (1394). The Effect of Sesamin on Motor Asymmetry in Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease. , 3(2), 5-8. doi: 10.22070/jbcp.2015.224
Tourandokht Baluchnejadmojarad; Monireh Mansouri; Farnaz Nikbakht; Soudabeh Fallah; Mehrdad Roghani. "The Effect of Sesamin on Motor Asymmetry in Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease". , 3, 2, 1394, 5-8. doi: 10.22070/jbcp.2015.224
Baluchnejadmojarad, Tourandokht, Mansouri, Monireh, Nikbakht, Farnaz, Fallah, Soudabeh, Roghani, Mehrdad. (1394). 'The Effect of Sesamin on Motor Asymmetry in Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease', , 3(2), pp. 5-8. doi: 10.22070/jbcp.2015.224
Baluchnejadmojarad, Tourandokht, Mansouri, Monireh, Nikbakht, Farnaz, Fallah, Soudabeh, Roghani, Mehrdad. The Effect of Sesamin on Motor Asymmetry in Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease. , 1394; 3(2): 5-8. doi: 10.22070/jbcp.2015.224

The Effect of Sesamin on Motor Asymmetry in Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease

Journal of Basic and Clinical Pathophysiology
مقاله 2، دوره 3، شماره 2، تیر 2015، صفحه 5-8    اصل مقاله (372.02 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22070/jbcp.2015.224
نویسندگان
Tourandokht Baluchnejadmojarad* 1؛ Monireh Mansouri1؛ Farnaz Nikbakht1؛ Soudabeh Fallah2؛ Mehrdad Roghani3
1Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
3Neurophysiology Research Center, Shahed University, Tehran, Iran
چکیده
Background and Objective: Parkinson's disease (PD) is an age-related neurodegenerative disease with selective damage of dopaminergic neurons of the mesencephalon. L-dihydroxyphenylamine (L-DOPA) therapy is currently the gold standard maneuver for PD. Due to the protective, anti-inflammatory, and antioxidant effect of sesamin, this study was undertaken to assess dose-dependent effect of this agent on motor asymmetry induced by intrastriatal injection of 6-hydroxydopamine in the rat.
Materials and Methods: In this experimental research, male Wistar rats (n=48) were equally divided into sham, sesamin20-treated sham, 6-hydroxydopamine (OHDA)-lesioned, sesamin10 and sesamin20-treated lesion groups, and sesamin20-treated lesion group receiving the estrogenic antagonist fulvestrant. Model of PD was induced by microinjecting 12.5 microgram of 6-OHDA dissolved in normal saline-ascorbate solution into the left striatum. Treated lesion groups received sesamin at doses of 10 or 20 mg/kg/day started one week till 1 h before the surgery. After 1 week, ipsilateral and contralateral rotations induced by apomorphine were counted and net scores were obtained.
Results: In the 6-OHDA-lesioned group, the dopaminergic agonist apomorphine induced contralateral rotational behavior (PConclusion: Sesamin administration at doses of 10 and 20 mg/kg could reduce motor asymmetry and attenuate forced biased rotational behavior in 6-OHDA-induced model of PD and part of this effect is possibly via an estrogenic pathway.
کلیدواژه‌ها
Sesamin؛ 6-hydroxydopamine؛ Rotational behavior؛ Motor asymmetry
آمار
تعداد مشاهده مقاله: 1,678
تعداد دریافت فایل اصل مقاله: 1,035