پروتئین شوک حرارتی؛ کاندید واکسن سرطان | ||
دانشور پزشکی | ||
مقاله 8، دوره 26، شماره 2 - شماره پیاپی 135، تیر 1397، صفحه 75-88 اصل مقاله (1.22 M) | ||
نویسندگان | ||
نسیم رحمانی کوکیا1؛ اردشیر عباسی* 2؛ زهیر محمد حسن2 | ||
1گروه بیوشیمی، دانشکده پزشکی، دانشگاه علوم پزشکی اردبیل، ایران | ||
2گروه ایمنیشناسی، دانشکده پزشکی، دانشگاه تربیت مدرس، ایران | ||
چکیده | ||
مقدمه و هدف: تومورها، آنتیژنهایی را بروز میدهند که توسط سیستم ایمنی به عنوان عامل بیگانه شناخته میشوند. پروتئینهای شوک حرارتی، چاپرون های مولکولی میباشند که با اتصال به آنتیژنهای توموری، جذب آنها را توسط سلولهای عرضه کننده آنتی ژن کنترل مینمایند. مواد و روشها: این مقاله، نوعی مقاله مروری بوده که در آن جمعآوری اطلاعات در زمینه ایمونوتراپی، سرطان و پروتئینهای شوک حرارتی به وسیله جستجو در اینترنت (Elsevier, Science, springer ) و به صورت محدود به زبان انگلیسی و با محدودیت زمانی (۲۰۰۰ به بعد) انجام گرفته. در میان مقالات بدست آمده از مؤلفین صاحبنظر و مجربی که مورد استناد واقع شده بودند، انتخاب گردیدند. نتایج: کمپلکس آنتی ژن- پروتئین شوک حرارتی با بکارگیری MHCІ و MHCII باعث فعال شدن لنفوسیت های T میگردد. فرآیندهای درگیر در جذب این کمپلکس که سبب عرضه متقاطع آنتی ژن شده، متفاوت از فرآیندهایی است که برای آنتی ژن منفرد مطرح است؛ بنابراین طبق نظریههای جدید، میتوان از این کمپلکس آنتی ژن- پروتئین شوک حرارتی به عنوان یکی از اجزاء واکسنهای توموری استفاده نمود. این واکسنها در ایمنیزایی علیه تومور نقش داشته و سبب برانگیختن پاسخهای مؤثرتر سیستم ایمنی و حفاظت علیه تومور میگردد. نتیجهگیری: با خالصسازی کمپلکس آنتی ژن-HSP < /span> از تومور خاص میتوان واکسن کارآمد و مؤثری علیه آن تومور ایجاد نمود. | ||
کلیدواژهها | ||
پروتئین شوک حرارتی؛ سرطان؛ واکسن | ||
مراجع | ||
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