1. Haines DD, Juhasz B, Tosaki A. Management of multi cellular senescence and oxidative stress. Journal of Cellular and Molecular Medicine 2013; 17( 8): 936–957. 2. Allender J, Rector C, Warner K. Community health nursing: promoting and protecting the public's health. Philadelphia, PA: Lippincott Williams & Wilkins 2013; 1227. 3. Elmore S. Apoptosis: a review of programmed cell death. Toxicologic Pathology 2007; 35(4):495-516. 4. Higami Y, Shimokawa I. Apoptosis in the aging process. Cell and Tissue Research 2000;301:125-132. 5. Liu M, Zhang P, Chen M, Zhang W, Yu L, Yang XC, et al. Aging might increase myocardial ischemia/reperfusion-induced apoptosis in humans and rats. Age (Dordr) 2012;34:621-632. 6. Biral D, J-Puka A, Betto R. Expression of Bcl-2 family proteins in recovering and regenerating muscles. Basic and Applied Myology 2002; 12 (1): 43-46. 7. Cheng EH, Wei MC, Weiler S. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Molecular Cell 2001; 8(3):705–711. 8. Carraro U, Franceschi C. Apoptosis of skeletal and cardiac muscles and physical exercise. Aging Clinical and Experimental Research 1997; 9:19 –34. 9. Mooren F, Völker Klaus C. Molecular and cellular exercise Physiology. Translated by: Tartibian Bakhtiar and colleagues. University of Urmia unit, 2012. 10. Fernandes T, Magalhaes FC, Everton CC. aerobic exercise training inhibits skeletal muscular apoptotic signaling mediated by VEGF-VEGR2 in spontaneously hypertensive rats. Exercise and Sports Sciences 2012; 18(6): 412-418. 11. Chen KC , peng CC, Hsieh CI , Robert Y , Peng C . Exercise Ameliorates Renal Cell Apoptosis in Chronic Kidney Disease by Intervening in the Intrinsic and the Extrinsic Apoptotic Pathways in a Rat Model. Evidence-Based Complementary and Alternative Medicine 2013:368450. 12. Zare A, Farzaneh P, Pourpak Z, Zahedi F, Moin M, Shahabi S, et al. Purified aged garlic extract modulates allergic airway inflammation in BALB/c mice. Iranian Journal of Allergy, Asthma and Immunology 2008;7:133-141. 13. Yeh YY, Yeh SM. Garlic reduces plasma lipids by inhibiting hepatic cholesterol and triacylglycerol synthesis. Lipids 1994;29: 189-193. 14. Seo DY, Kwak HB, Lee SR, Cho YS, Song IS, Kim N, et al. Effects of aged garlic extract and endurance exercise on skeletal muscle FNDC-5 and circulating irisin in high-fat-diet rat models . Nutrition Research and Practice 2014;8(2):177-182. 15. Al-Harbi NO, Imam F, Al-Harbi MM, Iqbal M, Nadeem A, Sayed-Ahmed MM, et al. Olmesartan Attenuates Tacrolimus-Induced Biochemical and Ultrastructural Changes in Rat Kidney Tissue. Bio Med Research International 2014;2014:607246. 16. Erasima k, Koukouvou G, Kouidi E. Exercise training in patients with end-stage renal disease on hemodialysis: comparison of three rehabilitaon programs. Journal Rehabil Medicine 2001; 34: 40- 45. 17. Foldes G, Horkay F, Szokodi I, Vuolteenaho O, Ilves M, Lindstedt KA. Circulating and Cardiac Levels of Apelin, the Novel Ligand of the Orphan Receptor APJ, in Patients with Heart Failure. Biochemical and Biophysical Research Communications 2003;308(3):480-485. 18. Segura E. Exercise in hemodyalysis patients: a literature systematic review. Nefrologia 2010;30(2):236-246. 19. Gavras H and Gavras I. Angiotensin Converting Enzyme inhibitors properties and side effects. Hypertension Supplements 1988; 11: 37-41. 20. Zhang J , Cai Xia Ren , Yong Fen Qi , Li Xia Lou , Li Chen , Li Ke Zhang et al. Exercise Training Promotes Expression of Apelin and APJ of Cardiovascular Tissues in Spontaneously Hypertensive Rats. Life Sciences 2006;79:1153-1159. 21. Mohammadi Gorji S, Karimpour AA. The effects of doxorubicin on the apoptotic Bcl2 and Bax gene expression in rat heart. Journal of Gorgan University of Medical Sciences 1392; 15:Issue 1(successive 45).]Persian[. 22. Chen X, Chen Y, Bi Y, Fu N, Shan C, Wang S. Preventive cardioprotection of erythropoietin against doxorubicin induced cardiomyopathy. Cardiovascular Drugs and Therapy 2007;21(5):367-374. 23. Green PS, Leeuwenburgh C. Mitochondrial dysfunction is an early indicator of doxorubicin-induced apoptosis. Biochimicaet Biophysica Acta 2002;1588(1):94-101. 24. Nicholson DW, Thornberry NA. Apoptosis. Life and death decisions Science 2003;299(5604):214-215. 25. Cory S, Huang CS, Adams JM.The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22( 53): 8590–8607. 26. Fussenegger M, Bailey JE, Varner J.A mathematical model of caspase function in apostosis. Nature Biotechnology 2000 ( 18): 768–774. 27. Liu M, Zhang P, Chen M, Zhang W, Yu L, Yang XC, et al. Aging might increase myocardial ischemia/reperfusion-induced apoptosis in humans and rats. Age (Dordr) 2012;34:621-632. 28. Song W, Kwak HB, Lawler JM. Exercise training attenuates age-induced changes in apoptotic signaling in rat skeletal muscle. Antioxidants & Redox Signaling 2006;8:517-528. 29. Kwak HB, Song W, Lawler JM. Exercise training attenuates age-induced elevation in Bax/Bcl-2 ratio, apoptosis, and remodeling in the rat heart. FASEB Journal 2006;20:791-793. 30. Nitahara JA, Cheng W, Liu Y, Li B, Leri A, Li P, et al. Intracellular calcium, DNase activity and myocyte apoptosis in aging Fischer 344 rats. Journal of Molecular and Cellular Cardiology 1998;30: 519-535. 31. Soufi FG, Farajnia S, Aslanabadi N, Ahmadiasl N, Alipour M, Alipour M, et al. Long-term exercise training affects age-induced changes in HSP70 and apoptosis in rat heart.General Physiology and Biophysics 2008;27:263-270. 32. Liu X, Kim CN, Yang J, Jemmerson R, Wang X. Induction of apoptotic program in cell-free extracts: requirement for ATP and cytochrome C. Cell 1996; 86(1):147–157. 33. Bongiorno PB, Fratellone PM, LoGiudice P: Potential health benefits of garlic (allium sativum): a narrative review. Journal of Complementary and Integrative Medicine 2008;5(1):1–26. 34. Capasso A: Antioxidant action and therapeutic efficacy of allium sativumL. Molecules 2013; 18(1):690–700. 35. Razo-Rodríguez AC, Chirino YI, Sánchez-González DJ, Martínez-Martínez CM, Cruz C, Pedraza-Chaverri J: Garlic powder ameliorates cisplatin-induced nephrotoxicity and oxidative stress. Journal of Medicinal Food 2008; 11(3):583–586. 36. Ray B, Chauhan NB, Lahiri DK. The “aged garlic extract:” (AGE) and one of its active ingredients S-allyl-L-cysteine (SAC) as potential preventive and therapeutic agents for Alzheimer's disease (AD) .Current Medicinal Chemistry 2011;18:3306–3313. 37. Zhang Y, Yao HP, Huang FF, Wu W, Gao Y, Chen ZB, et al. Allicin, a major component of garlic, inhibits apoptosis in vitalorgans in rats with trauma/hemorrhagic shock. Critical Care Medicine 2008;36(12):3226-3232. 38. Genesca` M, Sola A, Miquel R. Role ofchanges in tissular nucleotides on the devel-opment of apoptosis during ischemia/reperfusion in rat small bowel. American Journal of Pathology 2002; 161:1839 –1847. 39. Ikeda H, Suzuki Y, Suzuki M. Apoptosisis a major mode of cell death caused byischaemia and ischaemia/reperfusion injuryto the rat intestinal epithelium. Gut 1998;42:530 –537. 40. Oommen S, Anto RJ, Srinivas G. Allicin(from garlic) induces caspase-mediated apoptosis in cancer cells. European Journal of Pharmacology 2004;485:97–103. 41. Park SY, Cho SJ, Kwon HC. Caspase-independent cell death by allicin in humanepithelial carcinoma cells: involvement ofPKA. Cancer letters 2005; 224:123–132. 42. Cho SJ, Rhee DK, Pyo S: Allicin, a majorcomponent of garlic, inhibits apoptosis ofmacrophage in a depleted nutritional state. Nutrition 2006; 22:1177–1184. 43. Batirel HF, Naka Y, Kayano K. Intrave-nous allicin improves pulmonary blood flow after ischemia-reperfusion injury in rats. The Journal of cardiovascular surgery (Torino) 2002; 43:175–179. 44. Kaye AD, De Witt BJ, Anwar M. Analysisof responses of garlic derivatives in the pul-monary vascular bed of the rat. Journal of Applied Physiology 2000; 89:353–358.