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Baluchnejadmojarad, tourandokht, Jamali-Raeufy, Nida, Roghani, Mehrdad, Nikbakht, Farnaz, Ramazi, Samira, Zavvary, Fahimeh. (1393). Salvianolic Acid Improves Status Epilepticus and Learning and Memory Deficiency in Rat Model of Temporal Lobe Epilepsy. , 3(1), 39-46. doi: 10.22070/jbcp.2015.165
tourandokht Baluchnejadmojarad; Nida Jamali-Raeufy; Mehrdad Roghani; Farnaz Nikbakht; Samira Ramazi; Fahimeh Zavvary. "Salvianolic Acid Improves Status Epilepticus and Learning and Memory Deficiency in Rat Model of Temporal Lobe Epilepsy". , 3, 1, 1393, 39-46. doi: 10.22070/jbcp.2015.165
Baluchnejadmojarad, tourandokht, Jamali-Raeufy, Nida, Roghani, Mehrdad, Nikbakht, Farnaz, Ramazi, Samira, Zavvary, Fahimeh. (1393). 'Salvianolic Acid Improves Status Epilepticus and Learning and Memory Deficiency in Rat Model of Temporal Lobe Epilepsy', , 3(1), pp. 39-46. doi: 10.22070/jbcp.2015.165
Baluchnejadmojarad, tourandokht, Jamali-Raeufy, Nida, Roghani, Mehrdad, Nikbakht, Farnaz, Ramazi, Samira, Zavvary, Fahimeh. Salvianolic Acid Improves Status Epilepticus and Learning and Memory Deficiency in Rat Model of Temporal Lobe Epilepsy. , 1393; 3(1): 39-46. doi: 10.22070/jbcp.2015.165

Salvianolic Acid Improves Status Epilepticus and Learning and Memory Deficiency in Rat Model of Temporal Lobe Epilepsy

Journal of Basic and Clinical Pathophysiology
مقاله 7، دوره 3، شماره 1، اسفند 2014، صفحه 39-46    اصل مقاله (298.61 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22070/jbcp.2015.165
نویسندگان
tourandokht Baluchnejadmojarad* 1؛ Nida Jamali-Raeufy2؛ Mehrdad Roghani3؛ Farnaz Nikbakht4؛ Samira Ramazi4؛ Fahimeh Zavvary4
1TUMS, Tehran, Iran
2IUMS
3shahed
4iums
چکیده
Background and Objective: Epilepsy is a long-lasting central nervous system disorder that is accompany with spontaneous seizures and insufficiency in learning and memory. Now drug treatment is the most common therapy but some patients do not research to suitable control of their seizures with current drugs. Hence, new treatment is needed to help those patients that are unaffected to existing drugs. In present study, we evaluate the protective effect of pretreatment with salvianolic acid B in experimental model of temporal lobe epilepsy in male rats.
Materials & Methods: In the present study, the effect of intraperitoneal administration of salvianolic acid B (10 mg/kg) on induced seizures and learning and memory impairment induced by intrahippocampal injection of kainic acid (KA, 4 mg) were assessed in rats.
Results: Obtained data showed that the epileptic rats display kainic acid-induced seizures. On the other hand, in epileptic rats, spontaneous alternation score in Y maze tasks lowered (p<0.001) and retention and recall capability in the passive avoidance test impaired (p<0.05). Treatment of kainate rats with salvianolic acid B decreased the scale of induced seizures (p<0.01), improved alternation score (p<0.005) and retention and recall capability (p<0.01).
Conclusion: Taken together, this study reveals that treatment of kainate rats with salvianolic acid B could attenuates kainic acid-induced seizures and impairment of short-term spatial memory in rats.
کلیدواژه‌ها
Kainic acid؛ Salvianolic acid B؛ Passive avoidance؛ Y maze؛ Seizure؛ Rat
آمار
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