Administration of Salvianolic Acid B Attenuates Learning and Memory Deficits in Diabetic Rats: Involvement of Oxidative Stress | ||
Journal of Basic and Clinical Pathophysiology | ||
مقاله 6، دوره 2، شماره 2، تیر 2014، صفحه 43-50 اصل مقاله (209.88 K) | ||
نوع مقاله: Research Paper | ||
نویسندگان | ||
tourandokht Baluchnejadmojarad* 1؛ Nida Jamali-Raeufy2؛ Mehrdad Roghani3؛ Fahimeh zavvary4؛ Samira Ramazi4؛ Monireh Mansouri4 | ||
1TUMS, Tehran, Iran | ||
2IUMS | ||
3shahed | ||
4iums | ||
چکیده | ||
Background and Objective: Based on the effect of chronic metabolic diseases including diabetes mellitus on the learning and memory, this study was designed to assess the usefulness of administration of salvialonic acid B on lessening of learning and memory deficits in streptozotocin (STZ)-diabetic rats. Materials and Methods: Male Wistar rats were allocated into control, salvialonic acid B-treated control, diabetic and salvialonic acid B-treated diabetic groups. Salvialonic acid B was administered at a dose of 10 mg/kg/day for 8 weeks. Assessment of learning and memory was performed by Y maze and passive avoidance tests. Moreover, oxidative stress marker malondialdehyde (MDA) was also measured. Results: The results showed that in diabetic rats, alternation score in Y maze and retention and recall in passive avoidance test decreased in comparison with control rats (pConclusion: Taken together, these results show that salvialonic acid B could improve learning and memory deficits in STZ-diabetic rats by reduction of lipid peroxidation. | ||
کلیدواژهها | ||
Salvialonic acid B Learning and memory Streptozotocin | ||
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