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Taghizadeh, Reza, Haji Ebrahim Tehrani, Fatemeh, Ansari, Iman, Pirasteh, Ashraf. (1398). The relationship between thyroid hormones and procalcitonin with neonatal sepsis: a case-control study in Iran in 2017. , 7(2), 1-5. doi: 10.22070/jbcp.2019.4148.1111
Reza Taghizadeh; Fatemeh Haji Ebrahim Tehrani; Iman Ansari; Ashraf Pirasteh. "The relationship between thyroid hormones and procalcitonin with neonatal sepsis: a case-control study in Iran in 2017". , 7, 2, 1398, 1-5. doi: 10.22070/jbcp.2019.4148.1111
Taghizadeh, Reza, Haji Ebrahim Tehrani, Fatemeh, Ansari, Iman, Pirasteh, Ashraf. (1398). 'The relationship between thyroid hormones and procalcitonin with neonatal sepsis: a case-control study in Iran in 2017', , 7(2), pp. 1-5. doi: 10.22070/jbcp.2019.4148.1111
Taghizadeh, Reza, Haji Ebrahim Tehrani, Fatemeh, Ansari, Iman, Pirasteh, Ashraf. The relationship between thyroid hormones and procalcitonin with neonatal sepsis: a case-control study in Iran in 2017. , 1398; 7(2): 1-5. doi: 10.22070/jbcp.2019.4148.1111

The relationship between thyroid hormones and procalcitonin with neonatal sepsis: a case-control study in Iran in 2017

Journal of Basic and Clinical Pathophysiology
مقاله 1، دوره 7، شماره 2، اسفند 2019، صفحه 1-5    اصل مقاله (390.45 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22070/jbcp.2019.4148.1111
نویسندگان
Reza Taghizadeh1؛ Fatemeh Haji Ebrahim Tehrani2؛ Iman Ansari* 3؛ Ashraf Pirasteh4
1Medical Students Research Committee, Shahed University, Tehran, Iran
2Department of Pediatrics, Faculty of Medicine, Shahed University, Tehran, Iran
3Medical Students research committee, Shahed University, Tehran, Iran
4Department of Health & Social Medicine, Faculty of Medicine, Shahed University, Tehran, Iran
چکیده
Background and Objective: Neonatal sepsis (NS) is a major cause of mortality and morbidity in neonates. Correct and early diagnosis of NS can prevent its complications. The aim of this study was to investigate the relationship between the levels of thyroid hormones and procalcitonin (PCT) with NS.
Materials and Methods: In this case-control study, 40 term neonates with proven NS diagnosis and 40 term neonates whose NS were rejected due to negative paraclinical findings were compared in terms of thyroid hormone levels, PCT and C reactive protein (CRP). Data were analyzed using SPSS v.17.
Results: The most common clinical finding was fever in both groups, while there was no significant difference between the two groups (P = 0.1). The results of laboratory tests showed that the CRP levels ​​in the NS group were significantly higher than the control group (P = 0.03). In terms of thyroid hormones, although TSH and T4 were higher in the NS group, this difference was not statistically significant (P = 0.94 and P = 0.22, respectively). In addition, PCT measurements and comparisons showed that this parameter was significantly higher in the NS group (P = 0.01).
Conclusion:The results of this study demonstrated that CRP and PCT levels in NS neonates were significantly higher than non-NS neonates, while there was no significant difference in the level of thyroid hormones in the two groups. Further studies are recommended in this area.
Background and Objective: Neonatal sepsis (NS) is a major cause of mortality and morbidity in neonates. Correct and early diagnosis of NS can prevent its complications. The aim of this study was to investigate the relationship between the levels of thyroid hormones and procalcitonin (PCT) with NS.
Materials and Methods: In this case-control study, 40 term neonates with proven NS diagnosis and 40 term neonates whose NS were rejected due to negative paraclinical findings were compared in terms of thyroid hormone levels, PCT and C reactive protein (CRP). Data were analyzed using SPSS v.17.
Results: The most common clinical finding was fever in both groups, while there was no significant difference between the two groups (P = 0.1). The results of laboratory tests showed that the CRP levels ​​in the NS group were significantly higher than the control group (P = 0.03). In terms of thyroid hormones, although TSH and T4 were higher in the NS group, this difference was not statistically significant (P = 0.94 and P = 0.22, respectively). In addition, PCT measurements and comparisons showed that this parameter was significantly higher in the NS group (P = 0.01).
Conclusion: The results of this study demonstrated that CRP and PCT levels in NS neonates were significantly higher than non-NS neonates, while there was no significant difference in the level of thyroid hormones in the two groups. Further studies are recommended in this area.
کلیدواژه‌ها
Neonatal sepsis؛ Thyroid hormones؛ Procalcitonin؛ C-Reactive protein؛ Diagnosis
مراجع
  1. Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. The Lancet Respiratory Medicine 2018;6(3):223-230.
  2. UNICEF. The State of the World's Health 2009: Maternal and Newborn Health. UNICEF; 2009.
  3. Bizzaro MJ, Raskind C, Baltimore RS, Gallagher PG. Seventy-five years of neonatal sepsis at Yale: 1928-2003. Pediatrics 2005; pp: 595-602.
  4. Stoll K, Johns B. "Infections of the neonatal infant." Nelson textbook of pediatrics. 17th ed. Philadelphia Saunders 2004: 623-40.
  5. Mahallei M, Rezaee MA, Mehramuz B, Beheshtirooy S, Abdinia B. Clinical symptoms, laboratory, and microbial patterns of suspected neonatal sepsis cases in a children's referral hospital in northwestern Iran. Medicine (Baltimore) 2018;97(25):e10630.
  6. Farhadi R, Yaghobian M, Saravi BM. Clinical findings leading to the diagnosis of sepsis in neonates hospitalized in Imam Khomeini and Bu Ali hospitals, Sari, Iran: 2011-2012. Global Journal of Health Science 2014;6(4):298-303.
  7. Zea-Vera A, Ochoa TJ. Challenges in the diagnosis and management of neonatal sepsis. Journal of Tropical Pediatrics 2015;61(1):1-13.
  8. Obiero CW, Seale AC, Berkley JA. Empiric treatment of neonatal sepsis in developing countries. The Pediatric Infectious Disease Journal 2015;34(6):659-61.
  9. Amini M, Vaseie M, Ansari I. The evaluation of Nosocomial Urinary Tract Infections and Antimicrobial Resistance in ICU Patients, Tehran, Iran, 2012-2016. Acta Medica Mediterranea 2017; 33: 945-952.
  10. Amini M, Ansari I, Vaseie M, Vahidian M. Pattern of antibiotic resistance in nosocomial infections with Gram-negative bacilli in ICU patients (Tehran, Iran) during the years 2012-2014. Journal of Basic and Clinical Pathophysiology 2018; 6(1): 23-30.
  11. Pravin Charles MV, Kalaivani R, Venkatesh S, Kali A, Seetha KS. Evaluation of procalcitonin as a diagnostic marker in neonatal sepsis. Indian Journal of Pathology and Microbiology 2018;61(1):81-84.
  12. Sharma D, Farahbakhsh N, Shastri S, Sharma P. Biomarkers for diagnosis of neonatal sepsis: a literature review. The Journal of Maternal-Fetal & Neonatal Medicine 2018;31(12):1646-1659.
  13. Hofer N, Zacharias E, Müller W, Resch B. An update on the use of C-reactive protein in early-onset neonatal sepsis: current insights and new tasks. Neonatology 2012;102(1):25-36.
  14. Kordek A, Torbé A, Tousty J, Łoniewska B, Podraza W, Nikodemski T, et al. The Determination of Procalcitonin Concentration in Early-Onset Neonatal Infection. Clinical Pediatrics 2017;56(4):333-340.
  15. Tang BM, Eslick GD, Craig JC, McLean AS. Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis. The Lancet Infectious Diseases. 2007;7(3):210–17.
  16. Lodha R, Vivekanandhan S, Sarthi M, Arun S, Kabra SK. Thyroid function in children with sepsis and septic shock. Acta Paediatrica 2007; 96(3):406-9.
  17. Wang HC, Klein JR. Immune function of thyroid stimulating hormone and receptor. Critical Reviews in Immunology 2001; 21(4):323-37.
  18. Klein JR. Physiological relevance of thyroid stimulating hormone and thyroid stimulating hormone receptor in tissues other than the thyroid. Autoimmunity 2003; 36(6-7):417-21.
  19. Docter R, Krenning EP, de Jong M, Hennemann G. The sick euthyroid syndrome, changes in thyroid hormone serum parameters and hormone metabolism. Clinical Endocrinology 1993; 39: 499-518.
  20. Shahriarpanah S, Haji Ebrahim Tehrani F, Davati A, Ansari I. Effect of Phototherapy on Serum Level of Calcium, Magnesium and Vitamin D in Infants with Hyperbilirubinemia. Iranian Journal of Pathology 2018;13(3):357-362.
  21. Adib M, Bakhshiani Z, Navaei F, Saheb Fosoul F, Fouladi S, Kazemzadeh H. Procalcitonin: a reliable marker for the diagnosis of neonatal sepsis. Iranian Journal of Basic Medical Sciences 2012;15(2):777-82.
  22. Mohsen AH, Kamel BA. Predictive values for procalcitonin in the diagnosis of neonatal sepsis. Electronic Physician 2015;7(4):1190-5.
  23. Park IH, Lee SH, Yu ST, Oh YK. Serum procalcitonin as a diagnostic marker of neonatal sepsis. Korean Journal of Pediatrics 2014;57(10):451-6.
  24. Memar MY, Varshochi M, Shokouhi B, Asgharzadeh M, Kafil HS. Procalcitonin: The marker of pediatric bacterial infection. Biomedicine and Pharmacotherapy 2017;96:936-943.
  25. Yu Z, Liu J, Sun Q, Qiu Y, Han S, Guo X. The accuracy of the procalcitonin test for the diagnosis of neonatal sepsis: a meta-analysis. Scandinavian Journal of Infectious Diseases 2010;42(10):723-33.
  26. Kumar N, Dayal R, Singh P, Pathak S, Pooniya V, Goyal A, et al. A Comparative Evaluation of Presepsin with Procalcitonin and CRP in Diagnosing Neonatal Sepsis. Indian Journal of Pediatrics 2019;86(2):177-179.
  27. Quadir AF, Britton PN. Procalcitonin and C-reactive protein as biomarkers for neonatal bacterial infection. Journal of Paediatrics and Child Health 2018;54(6):695-699.
  28. Pontrelli G, De Crescenzo F, Buzzetti R, Jenkner A, Balduzzi S, Calò Carducci F, et al. Accuracy of serum procalcitonin for the diagnosis of sepsis in neonates and children with systemic inflammatory syndrome: a meta-analysis. BMC Infectious Diseases 2017;17(1):302.
  29. Ruan L, Chen GY, Liu Z, Zhao Y, Xu GY, Li SF, et al. The combination of procalcitonin and C-reactive protein or presepsin alone improves the accuracy of diagnosis of neonatal sepsis: a meta-analysis and systematic review. Critical Care 2018;22(1):316.
  30. Sharma S, Dabla PK, Kumar S, Dublis S. Thyroid Hormone Dysfunction and CRP Levels in Neonates with Sepsis. Journal of Endocrinology and Metabolism 2013;3(3):62-66.
  31. Kurt A, Aygun AD, Sengul I, Sen Y, Citak Kurt AN, Ustundag B. Serum thyroid hormones levels are significantly decreased in septic neonates with poor outcome. Journal of Endocrinological Investigation 2011;34(4):e92-6.
  32. Yildizdaş D, Onenli-Mungan N, Yapicioğlu H, Topaloğlu AK, Sertdemir Y, Yüksel B. Thyroid hormone levels and their relationship to survival in children with bacterial sepsis and septic shock. Journal of Pediatric Endocrinology and Metabolism 2004;17(10):1435-42.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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